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Review

Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

1
DSI/Mintek Nanotechnology Innovation Centre-Biolabels Node, Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
2
South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
3
Department of Chemistry, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Raul Colodner
Diagnostics 2021, 11(8), 1352; https://doi.org/10.3390/diagnostics11081352
Received: 14 June 2021 / Revised: 7 July 2021 / Accepted: 12 July 2021 / Published: 28 July 2021
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
The transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB diagnostic approaches, such as the culture, sputum smear, skin tuberculin, and molecular tests are time-consuming, and some are unaffordable for low-income countries. Rapid tests for disease biomarker detection are mostly based on immunological assays that use antibodies which are costly to produce, have low sensitivity and stability. Aptamers can replace antibodies in these diagnostic tests for the development of new rapid tests that are more cost effective; more stable at high temperatures and therefore have a better shelf life; do not have batch-to-batch variations, and thus more consistently bind to a specific target with similar or higher specificity and selectivity and are therefore more reliable. Advancements in TB research, in particular the application of proteomics to identify TB specific biomarkers, led to the identification of a number of biomarker proteins, that can be used to develop aptamer-based diagnostic assays able to screen individuals at the point-of-care (POC) more efficiently in resource-limited settings. View Full-Text
Keywords: tuberculosis; aptamers; diagnostics; lateral flow assays; point-of-care; biomarkers tuberculosis; aptamers; diagnostics; lateral flow assays; point-of-care; biomarkers
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MDPI and ACS Style

Martin, D.R.; Sibuyi, N.R.; Dube, P.; Fadaka, A.O.; Cloete, R.; Onani, M.; Madiehe, A.M.; Meyer, M. Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care. Diagnostics 2021, 11, 1352. https://doi.org/10.3390/diagnostics11081352

AMA Style

Martin DR, Sibuyi NR, Dube P, Fadaka AO, Cloete R, Onani M, Madiehe AM, Meyer M. Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care. Diagnostics. 2021; 11(8):1352. https://doi.org/10.3390/diagnostics11081352

Chicago/Turabian Style

Martin, Darius Riziki, Nicole Remaliah Sibuyi, Phumuzile Dube, Adewale Oluwaseun Fadaka, Ruben Cloete, Martin Onani, Abram Madimabe Madiehe, and Mervin Meyer. 2021. "Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care" Diagnostics 11, no. 8: 1352. https://doi.org/10.3390/diagnostics11081352

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