Next Article in Journal
Diagnostic Yield and Cost-Effectiveness of “Dynamic” Exome Analysis in Epilepsy with Neurodevelopmental Disorders: A Tertiary-Center Experience in Northern Italy
Next Article in Special Issue
Immunoreactivity of Polish Lyme Disease Patient Sera to Specific Borrelia Antigens—Part 1
Previous Article in Journal
Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer?
Article

Detection of Babesia odocoilei in Humans with Babesiosis Symptoms

1
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
2
Faculty of Veterinary Medicine, University of Agriculture, Faisalabad 38040, Pakistan
*
Author to whom correspondence should be addressed.
Academic Editors: Raphael B. Stricker and Raul Colodner
Diagnostics 2021, 11(6), 947; https://doi.org/10.3390/diagnostics11060947
Received: 21 March 2021 / Revised: 13 May 2021 / Accepted: 24 May 2021 / Published: 25 May 2021
(This article belongs to the Special Issue Lyme Disease: Companion Diagnostics and Precision Medicine)
Human babesiosis is a life-threatening infectious disease that causes societal and economic impact worldwide. Several species of Babesia cause babesiosis in terrestrial vertebrates, including humans. A one-day clinic was held in Ontario, Canada, to see if a red blood cell parasite, which is present in blacklegged ticks, Ixodes scapularis, is present in humans. Based on PCR testing and DNA sequencing of the 18S rRNA gene, we unveiled B. odocoilei in two of 19 participants. DNA amplicons from these two patients are almost identical matches with the type strains of B. odocoilei in GenBank. In addition, the same two human subjects had the hallmark symptoms of human babesiosis, including night sweats, chills, fevers, and profound fatigue. Based on symptoms and molecular identification, we provide substantive evidence that B. odocoilei is pathogenic to humans. Dataset reveals that B. odocoilei serologically cross-reacts with Babesia duncani. Clinicians must realize that there are more than two Babesia spp. in North America that cause human babesiosis. This discovery signifies the first report of B. odocoilei causing human babesiosis. View Full-Text
Keywords: Babesia odocoilei; piroplasm; human babesiosis; 18S rRNA; ticks; Ixodes scapularis; parasite; white-tailed deer; molecular identification; human pathogen Babesia odocoilei; piroplasm; human babesiosis; 18S rRNA; ticks; Ixodes scapularis; parasite; white-tailed deer; molecular identification; human pathogen
Show Figures

Figure 1

MDPI and ACS Style

Scott, J.D.; Sajid, M.S.; Pascoe, E.L.; Foley, J.E. Detection of Babesia odocoilei in Humans with Babesiosis Symptoms. Diagnostics 2021, 11, 947. https://doi.org/10.3390/diagnostics11060947

AMA Style

Scott JD, Sajid MS, Pascoe EL, Foley JE. Detection of Babesia odocoilei in Humans with Babesiosis Symptoms. Diagnostics. 2021; 11(6):947. https://doi.org/10.3390/diagnostics11060947

Chicago/Turabian Style

Scott, John D., Muhammad S. Sajid, Emily L. Pascoe, and Janet E. Foley 2021. "Detection of Babesia odocoilei in Humans with Babesiosis Symptoms" Diagnostics 11, no. 6: 947. https://doi.org/10.3390/diagnostics11060947

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop