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Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy

1
Department of Ophthalmology, Rostock University Medical Center, 18057 Rostock, Germany
2
Department Life, Light & Matter, University of Rostock, 18059 Rostock, Germany
3
Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine-Northwest, Gary, Indianapolis, IN 46204, USA
4
Eye Clinic, Johannes Wesling Klinikum Minden, Ruhr-University Bochum, 32429 Minden, Germany
5
Heart and Diabetes Center NRW, Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany
6
Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Zhen Cheng
Diagnostics 2021, 11(2), 154; https://doi.org/10.3390/diagnostics11020154
Received: 16 December 2020 / Revised: 15 January 2021 / Accepted: 19 January 2021 / Published: 21 January 2021
(This article belongs to the Section Medical Imaging)
In vivo large-area confocal laser scanning microscopy (CLSM) of the human eye using EyeGuidance technology allows a large-scale morphometric assessment of the corneal subbasal nerve plexus (SNP). Here, the SNP of a patient suffering from diabetes and associated late complications was analyzed. The SNP contained multiple clusters of large hyperintense, stellate-shaped, cellular-like structures. Comparable structures were not observed in control corneas from healthy volunteers. Two hypotheses regarding the origin of these atypical structures are proposed. First, these structures might be keratocyte-derived myofibroblasts that entered the epithelium from the underlying stroma through breaks in Bowman’s layer. Second, these structures could be proliferating Schwann cells that entered the epithelium in association with subbasal nerves. The nature and pathophysiological significance of these atypical cellular structures, and whether they are a direct consequence of the patient’s diabetic neuropathy/or a non-specific secondary effect of associated inflammatory processes, are unknown. View Full-Text
Keywords: in vivo large-area confocal laser scanning microscopy; subbasal nerve plexus; keratocyte-derived myofibroblasts; Schwann cells; diabetes in vivo large-area confocal laser scanning microscopy; subbasal nerve plexus; keratocyte-derived myofibroblasts; Schwann cells; diabetes
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MDPI and ACS Style

Sterenczak, K.A.; Stachs, O.; Marfurt, C.; Matuszewska-Iwanicka, A.; Stratmann, B.; Sperlich, K.; Guthoff, R.F.; Hettlich, H.-J.; Allgeier, S.; Stahnke, T. Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy. Diagnostics 2021, 11, 154. https://doi.org/10.3390/diagnostics11020154

AMA Style

Sterenczak KA, Stachs O, Marfurt C, Matuszewska-Iwanicka A, Stratmann B, Sperlich K, Guthoff RF, Hettlich H-J, Allgeier S, Stahnke T. Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy. Diagnostics. 2021; 11(2):154. https://doi.org/10.3390/diagnostics11020154

Chicago/Turabian Style

Sterenczak, Katharina A.; Stachs, Oliver; Marfurt, Carl; Matuszewska-Iwanicka, Aleksandra; Stratmann, Bernd; Sperlich, Karsten; Guthoff, Rudolf F.; Hettlich, Hans-Joachim; Allgeier, Stephan; Stahnke, Thomas. 2021. "Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy" Diagnostics 11, no. 2: 154. https://doi.org/10.3390/diagnostics11020154

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