Next Article in Journal
Congenital Afibrinogenemia and Hypofibrinogenemia: Laboratory and Genetic Testing in Rare Bleeding Disorders with Life-Threatening Clinical Manifestations and Challenging Management
Previous Article in Journal
Borderline Personality Disorder: Risk Factors and Early Detection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 11
Issue 11
10.3390/diagnostics11112143
Review Report
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Serum Biomarkers in Carotid Artery Disease

Diagnostics 2021, 11(11), 2143; https://doi.org/10.3390/diagnostics11112143
by Vassiliki I. Kigka 1, Vassiliki Potsika 1, Michalis Mantzaris 1, Vassilis Tsakanikas 1, Igor Koncar 2,3 and Dimitrios I. Fotiadis 1,4,*
Reviewer 2:
Attila Frigy
Diagnostics 2021, 11(11), 2143; https://doi.org/10.3390/diagnostics11112143
Submission received: 7 October 2021 / Revised: 11 November 2021 / Accepted: 15 November 2021 / Published: 18 November 2021
(This article belongs to the Section Medical Imaging and Theranostics)

Round 1

Reviewer 1 Report

please see the attached

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Article:

Serum Biomarkers in Carotid Artery Disease

 Abstract

Please remake (not clear): In this paper, our aim is to present all the available in the literature circulating biomarkers for the diagnosis and the prognosis of carotid artery disease. These biomarkers are derived by clinical based studies and statistical analyses.

Introduction

Please remake (not clear): Biomarkers to be considered as surrogate ones for clinical significant cardiovascular endpoints should satisfy several criteria, such as proof of concept, prospective validation, incremental value, clinical utility, clinical outcomes, cost-effectiveness, ease of use, methodological consensus, and reference values

Inflammatory biomarkers – please rewrite

The first two sentences.

? acute anterior circulation cerebral infarction

?Additionally, IL-6 showed to be  associated with the presence of ICA stenosis [9], and also through a genetic association study, it was indicated that IL-6 is associated with ICA stenosis [17].

These are just a couple of examples for not proper composition.

…………………..

The text is very rich in information, but the composition of sentences makes it very hard to be read. There is redundancy, the text is not properly organized, the tables are full with too more data.

Keeping in mind, that the topic is interesting for a large number of readers, I suggest rewriting the manuscript with careful English proofreading, to be more concise, more clear-cut, and the tables to be more simple and clear.

The discussion repeats the data presented previously.  Instead, the personal view of the authors regarding practical aspects (which biomarker to use, and when, in which patient), would have been welcome.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

I think, the authors properly have solved the problems I mentioned in the review.

Back to TopTop