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Volume 11
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10.3390/diagnostics11010070
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Article

Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors

by
Federico Bruno
1,*,
Alessandra Splendiani
1,
Emanuele Tommasino
1,
Massimiliano Conson
2,
Mario Quarantelli
3,
Gennaro Saporito
1,
Antonio Carolei
1,
Simona Sacco
1,
Ernesto Di Cesare
1,
Antonio Barile
1,
Carlo Masciocchi
1 and
Francesca Pistoia
1
1
Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
2
Laboratory of Developmental Neuropsychology, Department of Psychology, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy
3
Institute of Biostructure and Bioimaging, National Research Council, 80100 Naples, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 70; https://doi.org/10.3390/diagnostics11010070
Submission received: 2 December 2020 / Revised: 20 December 2020 / Accepted: 28 December 2020 / Published: 4 January 2021
(This article belongs to the Section Medical Imaging and Theranostics)
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Abstract

Moving from the central role of the thalamus in the integration of inner and external stimuli and in the implementation of a stress-related response, the objective of the present study was to investigate the presence of any MRI structural and volumetric changes of the thalamic structures in earthquake witnesses. Forty-one subjects were included, namely 18 university students belonging to the experimental earthquake-exposed group (8 males and 10 females, mean age 24.5 ± 1.8 years) and a control group of 23 students not living in any earthquake-affected areas at the time of the earthquake (14 males and 9 females, mean age 23.7 ± 2.0 years). Instrumental MRI evaluation was performed using a 3-Tesla scanner, by acquiring a three-dimensional fast spoiled gradient-echo (FSPGR) sequence for volumetric analysis and an EPI (echoplanar imaging) sequence to extract fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values. As compared to the control one, the experimental group showed significantly lower gray matter volume in the mediodorsal nucleus of the left thalamus (p < 0.001). The dominant hemisphere thalamus in the experimental group showed higher mean ADC values and lower mean FA values as compared to the control group.
Keywords: thalamus; trauma; stress; earthquake; MRI; DTI; DWI; brain volumes thalamus; trauma; stress; earthquake; MRI; DTI; DWI; brain volumes

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MDPI and ACS Style

Bruno, F.; Splendiani, A.; Tommasino, E.; Conson, M.; Quarantelli, M.; Saporito, G.; Carolei, A.; Sacco, S.; Di Cesare, E.; Barile, A.; et al. Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors. Diagnostics 2021, 11, 70. https://doi.org/10.3390/diagnostics11010070

AMA Style

Bruno F, Splendiani A, Tommasino E, Conson M, Quarantelli M, Saporito G, Carolei A, Sacco S, Di Cesare E, Barile A, et al. Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors. Diagnostics. 2021; 11(1):70. https://doi.org/10.3390/diagnostics11010070

Chicago/Turabian Style

Bruno, Federico, Alessandra Splendiani, Emanuele Tommasino, Massimiliano Conson, Mario Quarantelli, Gennaro Saporito, Antonio Carolei, Simona Sacco, Ernesto Di Cesare, Antonio Barile, and et al. 2021. "Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors" Diagnostics 11, no. 1: 70. https://doi.org/10.3390/diagnostics11010070

APA Style

Bruno, F., Splendiani, A., Tommasino, E., Conson, M., Quarantelli, M., Saporito, G., Carolei, A., Sacco, S., Di Cesare, E., Barile, A., Masciocchi, C., & Pistoia, F. (2021). Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors. Diagnostics, 11(1), 70. https://doi.org/10.3390/diagnostics11010070

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