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Open AccessArticle

Diagnostic Performance of F18-FDG PET/CT in Male Breast Cancers Patients

1
Department of Medical Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
2
PhD School of Iuliu Hatieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
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Department of Endocrine Tumors and Nuclear Medicine, Institute of Oncology, 400012 Cluj-Napoca, Romania
4
Departement of Oral Health, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
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Department of Surgery, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
6
Department of Mother and Child, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 119; https://doi.org/10.3390/diagnostics11010119
Received: 13 December 2020 / Revised: 7 January 2021 / Accepted: 11 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
Introduction: F18-FDG PET/CT is the most important hybrid imaging used in the diagnostic, staging, follow-up, and treatment evaluation response in cancer patients. However, it is well-known that in breast cancer the use of F18-FDG is not included in the first line protocol of initial diagnostic, both in female and male breast cancer patients. F18-FDG PET/CT is a valuable tool to provide information on extra-axillary lymph node involvement, distant metastases, and other occult primary cancers. This study assesses F18-FDG PET/CT systemic staging in male patients with diagnosed breast cancer and determines detection rates for unsuspected distant metastases and synchronous malignancies. Methods: We analyzed a number of 170 male patients with breast cancer, seen between 2000–2020, in a tertiary center. From this group, between 2013–2020 a number of 23 patients underwent F18-FDG PET/CT. Rates of upstaging were determined for each case and the detection of other primary malignancies was analyzed. Results: Median age of male breast cancer group was 61.3 y (range, 34–85 y), most had intraductal carcinoma (82.4%) and unsuspected distant metastases, which increased patient stage to IV, observed in 27%. In 4 out 23 patients (17.4%), F18-FDG PET/CT identified synchronous cancers (2 prostate cancers, 1 thyroid and 1 colon cancer). Conclusion: F18-FDG PET/CT is a valuable tool to provide information on extra-axillary lymph node involvement, distant metastases, and other occult primary cancers. Baseline F18-FDG PET/CT has a substantial impact on the initial staging and on clinical management in male breast patients and should be considered for use in newly diagnosed patients. View Full-Text
Keywords: male breast cancer; synchronous malignancies; F18-FDG PET/CT male breast cancer; synchronous malignancies; F18-FDG PET/CT
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MDPI and ACS Style

Piciu, A.; Piciu, D.; Polocoser, N.; Kovendi, A.A.; Almasan, I.; Mester, A.; Morariu, D.-S.; Cainap, C.; Cainap, S.S. Diagnostic Performance of F18-FDG PET/CT in Male Breast Cancers Patients. Diagnostics 2021, 11, 119. https://doi.org/10.3390/diagnostics11010119

AMA Style

Piciu A, Piciu D, Polocoser N, Kovendi AA, Almasan I, Mester A, Morariu D-S, Cainap C, Cainap SS. Diagnostic Performance of F18-FDG PET/CT in Male Breast Cancers Patients. Diagnostics. 2021; 11(1):119. https://doi.org/10.3390/diagnostics11010119

Chicago/Turabian Style

Piciu, Andra; Piciu, Doina; Polocoser, Narcis; Kovendi, Anita A.; Almasan, Iulia; Mester, Alexandru; Morariu, Dragos-Stefan; Cainap, Calin; Cainap, Simona S. 2021. "Diagnostic Performance of F18-FDG PET/CT in Male Breast Cancers Patients" Diagnostics 11, no. 1: 119. https://doi.org/10.3390/diagnostics11010119

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