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Article

Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing

1
Clinic for Anesthesiology and Surgical Intensive Care, University Hospital Halle (Saale), 06120 Halle, Germany
2
Core Unit DNA Technologies, Medical Faculty, Leipzig University, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(9), 701; https://doi.org/10.3390/diagnostics10090701
Received: 3 September 2020 / Accepted: 14 September 2020 / Published: 16 September 2020
(This article belongs to the Special Issue Diagnosis and Management of Sepsis)
Sepsis represents a serious medical problem accounting for numerous deaths of critically ill patients in intensive care units (ICUs). An early, sensitive, and specific diagnosis is considered a key element for improving the outcome of sepsis patients. In addition to classical laboratory markers, ICU scoring systems and serum miRNAs are discussed as potential sepsis biomarkers. In the present prospective observational study, the suitability of miRNAs in sepsis diagnosis was tested based on proper validated and normalized data (i.e., absolute quantification by means of Droplet Digital PCR (ddPCR)) in direct comparison to classical sepsis markers and ICU scores within the same patient cohort. Therefore, blood samples of septic intensive care patients (n = 12) taken at day of admission at ICU were compared to non-septic intensive care patients (n = 12) and a healthy control group (n = 12). Our analysis indicates that all tested biomarkers have only a moderate informative power and do not allow an unequivocal differentiation between septic and non-septic ICU patients. In conclusion, there is no standalone laboratory parameter that enables a reliable diagnosis of sepsis. miRNAs are not superior to classical parameters in this respect. It seems recommendable to measure multiple parameters and scores and to interpret them with regard to the clinical presentation. View Full-Text
Keywords: sepsis; inflammation; biomarker; sequential organ failure assessment (SOFA) score; miRNA; cytokines sepsis; inflammation; biomarker; sequential organ failure assessment (SOFA) score; miRNA; cytokines
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MDPI and ACS Style

Link, F.; Krohn, K.; Burgdorff, A.-M.; Christel, A.; Schumann, J. Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing. Diagnostics 2020, 10, 701. https://doi.org/10.3390/diagnostics10090701

AMA Style

Link F, Krohn K, Burgdorff A-M, Christel A, Schumann J. Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing. Diagnostics. 2020; 10(9):701. https://doi.org/10.3390/diagnostics10090701

Chicago/Turabian Style

Link, Fabian, Knut Krohn, Anna-Maria Burgdorff, Annett Christel, and Julia Schumann. 2020. "Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing" Diagnostics 10, no. 9: 701. https://doi.org/10.3390/diagnostics10090701

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