Ultrasound Assessment of Hepatic Steatosis by Using the Double Nakagami Distribution: A Feasibility Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Double Nakagami Distribution
2.2. Clinical Subjects
2.3. Ultrasound Data Processing
2.4. Statistical Analysis
3. Results
4. Discussion
4.1. Significance of this Study
4.2. The Dependency of the DND Parameter on Hepatic Steatosis
4.3. Comparisons between the Conventional Nakagami and DND Parameters
4.4. Limitations and Future Work
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Characteristics | Value |
---|---|
Male/Female | 129/75 |
Age, years | |
Mean ± standard deviation (range) | 57.75 ± 11.08 (31–81) |
Median | 58 |
BMI, kg/m2 | |
Mean ± standard deviation (range) | 25.38± 3.91 (16.82–37.83) |
Median | 24.91 |
AST, U/L | |
Mean ± standard deviation (range) | 67.39 ± 68.04 (15–507) |
Median | 46 |
ALT, U/L | |
Mean ± standard deviation (range) | 87.64 ± 99.33 (8–595) |
Median | 53 |
Histological grade, no. of patients | |
Normal | 80 |
Mild | 70 |
Moderate | 36 |
Severe | 18 |
Metavir score, no. of patients | |
F0 | 16 |
F1 | 40 |
F2 | 46 |
F3 | 61 |
F4 | 41 |
Parameter | m | mF(KL) | mF(EM) | ||||||
---|---|---|---|---|---|---|---|---|---|
≥ Mild | ≥ Moderate | ≥ Severe | ≥ Mild | ≥ Moderate | ≥ Severe | ≥ Mild | ≥ Moderate | ≥ Severe | |
Cutoff value | 0.71 | 0.77 | 0.79 | 0.80 | 0.88 | 0.94 | 0.96 | 1.03 | 1.04 |
Sensitivity, % | 73.75 | 73.33 | 68.82 | 68.75 | 69.33 | 74.73 | 68.75 | 71.33 | 68.28 |
Specificity, % | 70.16 | 81.18 | 83.33 | 71.77 | 81.48 | 77.78 | 75 | 77.78 | 83.33 |
LR+ | 2.47 | 3.96 | 4.13 | 2.44 | 3.74 | 3.36 | 2.75 | 3.21 | 4.10 |
LR− | 0.37 | 0.33 | 0.37 | 0.44 | 0.38 | 0.32 | 0.42 | 0.37 | 0.38 |
PPV, % | 61.46 | 91.67 | 97.71 | 61.11 | 91.23 | 97.20 | 63.95 | 89.92 | 97.69 |
NPV, % | 80.56 | 52.38 | 20.55 | 78.07 | 48.89 | 22.95 | 78.81 | 49.41 | 20.27 |
AUROC (95% CI) | 0.75 (0.69–0.83) | 0.82 (0.77–0.88) | 0.82 (0.74–0.90) | 0.76 (0.69–0.83) | 0.81 (0.75–0.87) | 0.82 (0.74–0.90) | 0.76 (0.69–0.83) | 0.81 (0.75–0.87) | 0.82 (0.74–0.90) |
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Fang, F.; Fang, J.; Li, Q.; Tai, D.-I.; Wan, Y.-L.; Tamura, K.; Yamaguchi, T.; Tsui, P.-H. Ultrasound Assessment of Hepatic Steatosis by Using the Double Nakagami Distribution: A Feasibility Study. Diagnostics 2020, 10, 557. https://doi.org/10.3390/diagnostics10080557
Fang F, Fang J, Li Q, Tai D-I, Wan Y-L, Tamura K, Yamaguchi T, Tsui P-H. Ultrasound Assessment of Hepatic Steatosis by Using the Double Nakagami Distribution: A Feasibility Study. Diagnostics. 2020; 10(8):557. https://doi.org/10.3390/diagnostics10080557
Chicago/Turabian StyleFang, Feng, Jui Fang, Qiang Li, Dar-In Tai, Yung-Liang Wan, Kazuki Tamura, Tadashi Yamaguchi, and Po-Hsiang Tsui. 2020. "Ultrasound Assessment of Hepatic Steatosis by Using the Double Nakagami Distribution: A Feasibility Study" Diagnostics 10, no. 8: 557. https://doi.org/10.3390/diagnostics10080557