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Open AccessArticle

Programmed Death Ligand 1: A Poor Prognostic Marker in Endometrial Carcinoma

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia
Department of Pathology, Hospital Raja Permaisuri Bainun, Jalan Raja Ashman Shah, Ipoh 30450, Perak Darul Ridzuan, Malaysia
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 394;
Received: 19 April 2020 / Revised: 24 May 2020 / Accepted: 9 June 2020 / Published: 11 June 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Endometrial carcinoma is the only gynaecologic malignancy with a raising incidence and mortality, posing a major health concern worldwide. The upregulation of programmed death ligand 1 (PD-L1) on tumour cells causes T-cell suppression, which impedes antitumour immunity, promotes immune cell evasion and enhances tumour survival. The aim of this study was to evaluate PD-L1 expression in endometrial carcinoma and to correlate it with survival rate. A total of 59 cases of endometrial carcinoma were evaluated. Thirty-two cases of non-neoplastic endometrial tissue were included as control. PD-L1 immunohistochemistry was performed on all cases. PD-L1 expression was evaluated on tumour cells and immune cells. PD-L1 was positive in 62.7% (37/59) and 28.8% (17/59) of immune cells and tumour cells, respectively. PD-L1 expression in immune cells was significantly higher in endometrial carcinoma than in non-neoplastic endometrium (p < 0.001). Among the patients with endometrial carcinoma, PD-L1 expression in tumour cells was significantly higher in patients who died (10/15, 66.7%) compared to those who survived (7/44, 15.9%) (p < 0.001). It is noteworthy to point out that the expression of PD-L1 in tumour cells was significantly associated with a poor survival. This suggests that immunomodulation using PD-L1 inhibitors may be useful in advanced endometrial carcinoma. View Full-Text
Keywords: endometrial carcinoma; PD-L1; prognostic factor; gynaecology; pathology endometrial carcinoma; PD-L1; prognostic factor; gynaecology; pathology
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Chew, M.; Wong, Y.P.; Karim, N.; Mustangin, M.; Alfian, N.; Tan, G.C. Programmed Death Ligand 1: A Poor Prognostic Marker in Endometrial Carcinoma. Diagnostics 2020, 10, 394.

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