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Open AccessArticle

Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Endometriosis Menstrual Blood

1
Department of Obstetrics and Gynecology, Hasan Sadikin General Hospital—Universitas Padjadjaran, Bandung 40161, Indonesia
2
Department of Pathology, Hasan Sadikin General Hospital—Universitas Padjadjaran, Bandung 40161, Indonesia
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 364; https://doi.org/10.3390/diagnostics10060364
Received: 14 April 2020 / Revised: 26 May 2020 / Accepted: 1 June 2020 / Published: 2 June 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Endometriosis is a gynecological disease characterized by the presence of endometrial-like tissue outside the uterine cavity. Remodeling of the extracellular matrix (ECM) is a prerequisite for tissue implantation. The presence of matrix metalloproteinase (MMP) and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), in shed endometrium cells has a significant role in ECM degradation. A case–control study was performed to find other diagnostic markers using menstrual blood. We examined a sample of 68 women who visited the gynecology clinic in Dr Hasan Sadikin General Hospital, 40% of whom were confirmed to have endometriosis, and the rest tested negative by histopathological examination. All endometriotic cases presented MMP-9 and TIMP-1 expression with different cell distribution. MMP-9 expression in endometriosis patients was increased compared to the controls (p = 0.002). Expression of MMP-9 in >80% of endometrial cells was associated with a higher risk for endometriosis (OR 4.44 95% CI 1.31 to 15.56) compared to MMP-9 expression in 50%–80% of cells. TIMP-1 cell expression in women with endometriosis was lower than in the control group (p = 0.030). Subjects with TIMP-1 expression in 20%–50% of endometrial cells had a higher risk for endometriosis (OR 4.5, 95%CI 1.21–17.42) compared those with TIMP-1 expression in 50%–80% of cells. These expressions levels can be useful to predict endometriosis. View Full-Text
Keywords: MMP-9; TIMP-1; endometriosis MMP-9; TIMP-1; endometriosis
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Madjid, T.H.; Ardiansyah, D.F.; Permadi, W.; Hernowo, B. Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Endometriosis Menstrual Blood. Diagnostics 2020, 10, 364.

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