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Open AccessArticle

Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness

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State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, Russia
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G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov Sr., 10, 125212 Moscow, Russia
3
All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, 117216 Moscow, Russia
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(5), 336; https://doi.org/10.3390/diagnostics10050336
Received: 27 April 2020 / Revised: 14 May 2020 / Accepted: 21 May 2020 / Published: 24 May 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%). View Full-Text
Keywords: androgenic alopecia; zinc; minoxidil; trace elements; hormones; hair follicles androgenic alopecia; zinc; minoxidil; trace elements; hormones; hair follicles
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MDPI and ACS Style

Kondrakhina, I.N.; Verbenko, D.A.; Zatevalov, A.M.; Gatiatulina, E.R.; Nikonorov, A.A.; Deryabin, D.G.; Kubanov, A.A. Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness. Diagnostics 2020, 10, 336.

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