Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Participants and Institutional Review Board Approval
2.2. Inclusion and Exclusion Criteria
2.3. Ophthalmological Examinations
2.4. Patient Interviews for DE-Related Symptoms
2.5. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
DE | dry eye |
TBUT | tear break-up time |
MGD | meibomian gland dysfunction |
ADDE | aqueous deficit dry eye |
EDE | evaporative dry eye |
References
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Age (Years) | Sex | Dry Eye Medication | |||
---|---|---|---|---|---|
Men (n = 159) | Women (n = 545) | Hyaluronate | Mucin Secretagogue | Steroid | |
≤29 | 16 (10.1) | 51 (9.4) | 22 (32.8) | 14 (20.9) | 9 (13.4) |
30–39 | 24 (15.1) | 58 (10.6) | 16 (19.5) | 23 (28.0) | 5 (6.1) |
40–49 | 31 (19.5) | 76 (13.9) | 30 (28.0) | 24 (22.4) | 9 (8.4) |
50–59 | 33 (20.8) | 114 (20.9) | 44 (29.9) | 49 (33.3) | 13 (8.8) |
60–69 | 25 (15.7) | 114 (20.9) | 39 (28.1) | 49 (35.3) | 13 (9.4) |
≥70 | 30 (18.8) | 132 (24.3) | 47 (29.0) | 51 (31.5) | 12 (7.4) |
p value * | 0.019 | 0.731 | 0.041 | 0.543 |
Dryness | Irritation | Pain | Eye Fatigue | Blurring | Photophobia | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | |
Age (years) | ||||||||||||
≤29 | 36/67 (53.7) | 1 | 26/67 (38.8) | 1 | 20/67 (29.8) | 1 | 30/67 (44.8) | 1 | 16/67 (23.9) | 1 | 21/67 (31.3) | 1 |
30–39 | 45/82 (54.2) | 1.04 (0.54–2.00) | 22/82 (26.8) | 0.57 (0.28–1.14) | 14/82 (17.1) | 0.51 (0.23–1.12) | 46/82 (56.1) | 1.51 (0.78–2.90) | 26/82 (31.7) | 1.48 (0.71–3.09) | 23/82 (28.0) | 0.89 (0.43–1.82) |
40–49 | 48/107 (44.9) | 0.69 (0.3–1.29) | 31/107 (29.2) | 0.64 (0.33–1.22) | 17/107 (16.0) | 0.47 (0.22–1.00) | 54/107 (50.9) | 1.21 (0.65–2.26) | 35/107 (33.0) | 1.53 (0.76–3.06) | 28/107 (26.4) | 0.80 (0.40–1.59) |
50–59 | 59/147 (40.1) | 0.55 * (0.3–0.99) | 32/147 (21.8) | 0.42 * (0.22–0.80) | 20/147 (13.6) | 0.38 * (0.19–0.79) | 87/147 (59.2) | 1.74 (0.97–3.13) | 44/147 (29.9) | 1.35 (0.69–2.65) | 37/147 (25.2) | 0.77 (0.40–1.48) |
60–69 | 52/139 (37.4) | 0.50 * (0.27–0.90) | 49/139 (35.2) | 0.81 (0.44–1.49) | 20/139 (14.4) | 0.41 * (0.20–0.84) | 59/139 (42.2) | 0.91 (0.5–1.65) | 43/139 (30.9) | 1.43 (0.73–2.80) | 33/139 (23.7) | 0.74 (0.38–1.43) |
≥70 | 35/162 (21.7) | 0.22 * (0.11–0.41) | 47/162 (29.7) | 0.63 (0.34–1.16) | 22/162 (13.8) | 0.37 (0.18–0.76) | 71/162 (44.1) | 0.96 (0.53–1.71) | 50/162 (31.6) | 1.45 (0.75–2.80 | 31/162 (19.7) | 0.57 (0.29–1.10) |
Sex | ||||||||||||
Male | 44/159 (27.7) | 1 | 29/159 (18.2) | 1 | 18/159 (11.3) | 1 | 80/159 (50.3) | 1 | 47/159 (29.6) | 1 | 36/159 (22.6) | 1 |
Female | 231/545 (42.4) | 2.15 * (1.44–3.21 | 178/545 (32.7) | 2.22 * (1.42–3.45) | 95/545 (17.4) | 1.75 * (1.02–3.01) | 267/545 (49.0) | 0.96 (0.67–1.37) | 167/545 (30.6) | 1.05 (0.71–1.55) | 137/545 (25.1) | 1.20 (0.78–1.83) |
Corneal parameters | ||||||||||||
TBUT (≤5 s) | 208/275 (75.6) | 1.44 * (1.01–2.06) | 158/207 (76.3) | 1.36 (0.93–1.99) | 84/113 (74.3) | 1.19 (0.75–1.90) | 251/347 (72.3) | 1.16 (0.83–1.61) | 177/214 (82.7) | 2.53 * (1.69–3.80) | 142/173 (82.0) | 2.28 * (1.48–3.53) |
Keratopathy score (≥3) | 128/275 (46.5) | 1.62 * (1.17–2.24) | 102/207 (49.2) | 1.74 * (1.25–2.43) | 57/113 (50.4) | 1.70 * (1.13–2.56) | 132/347 (38.0) | 0.93 (0.69–1.27) | 82/214 (38.3) | 0.99 (0.71–1.38) | 68/173 (39.3) | 1.00 (0.70–1.42) |
Schirmer’s test value (≤5 mm) | 94/275 (34.1) | 1.39 (0.99–1.95) | 71/207 (34.3) | 1.22 (0.86–1.73) | 28/113 (24.7) | 0.71 (0.44–1.14) | 100/347 (28.8) | 1.02 (0.71–1.46) | 69/214 (32.2) | 1.08 (0.76–1.531) | 42/173 (24.2) | 0.66 (0.44–0.98) |
Short TBUT | Keratopathy Score | Low Schirmer’s Test Value | ||||
---|---|---|---|---|---|---|
Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | Prevalence (%) | OR (95% CI) | |
Age (years) | ||||||
≤29 | 40/67 (59.7) | 1 | 33/67 (49.2) | 1 | 13/67 (19.4) | 1 |
30–39 | 51/82 (62.2) | 1.15 (0.59–2.23) | 28/82 (35.0) | 0.58 (0.29–1.13) | 19/82 (23.1) | 1.25 (0.56–2.77) |
40–49 | 84/107 (78.5) | 2.63 * (1.33–5.20) | 44/107 (41.5) | 0.77 (0.41–1.44) | 33/107 (30.8) | 1.84 (0.88–3.84) |
50–59 | 109/147 (74.1) | 1.98 * (1.07–3.66) | 49/147 (33.3) | 0.52 * (0.28–0.95) | 49/147 (33.3) | 2.03 * (1.01–4.08) |
60–69 | 107/139 (77.0) | 2.24 * (1.18–4.24) | 51/139 (36.6) | 0.59 (0.32–1.08) | 56/139 (40.3) | 2.74 * (1.36–5.50) |
≥70 | 108/162 (66.6) | 1.34 (0.73–2.43) | 66/162 (41.0) | 0.71 (0.40–1.28) | 46/162 (28.4) | 1.60 (0.80–3.22) |
Sex | ||||||
Male | 93/159 (58.5) | 1 | 45/159 (28.3) | 1 | 42/159 (26.4) | 1 |
Female | 406/545 (74.5) | 2.06 * (1.42–2.98) | 226/545 (41.5) | 1.82 * (1.23–2.68) | 174/545 (31.9) | 1.27 (0.85–1.89) |
Age Group | Symptoms | Signs | |||
---|---|---|---|---|---|
Non-Visual | Visual | Keratopathy | Short TBUT | Aqueous Tear Deficiency | |
Younger (≤29 years) | +++ | + | ++ | + | + |
Middle-aged (30–49 years) | ++ | + | + | ++ | ++ |
Older (≥50 years) | + | + | + | ++ | +++ |
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Share and Cite
Ayaki, M.; Negishi, K.; Kawashima, M.; Uchino, M.; Kaido, M.; Tsubota, K. Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms. Diagnostics 2020, 10, 193. https://doi.org/10.3390/diagnostics10040193
Ayaki M, Negishi K, Kawashima M, Uchino M, Kaido M, Tsubota K. Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms. Diagnostics. 2020; 10(4):193. https://doi.org/10.3390/diagnostics10040193
Chicago/Turabian StyleAyaki, Masahiko, Kazuno Negishi, Motoko Kawashima, Miki Uchino, Minako Kaido, and Kazuo Tsubota. 2020. "Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms" Diagnostics 10, no. 4: 193. https://doi.org/10.3390/diagnostics10040193
APA StyleAyaki, M., Negishi, K., Kawashima, M., Uchino, M., Kaido, M., & Tsubota, K. (2020). Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms. Diagnostics, 10(4), 193. https://doi.org/10.3390/diagnostics10040193