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Open AccessArticle

Analysis of Let-7 Family miRNA in Plasma as Potential Predictive Biomarkers of Diagnosis for Papillary Thyroid Cancer

1
Department of Cardiovascular Physiology, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland
2
Department of Clinical Physiology, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland
3
Department of General and Oncological Surgery, Medical University of Lodz, 92-213 Lodz, Poland
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(3), 130; https://doi.org/10.3390/diagnostics10030130
Received: 7 February 2020 / Revised: 25 February 2020 / Accepted: 26 February 2020 / Published: 28 February 2020
(This article belongs to the Special Issue New Insights in Thyroid Diagnostics)
The most common histological type of thyroid cancer is papillary thyroid carcinoma (PTC). Radical resection of the thyroid gland is currently the recommended method of treatment. Almost 75% of thyroidectomies performed just for diagnostic purposes are benign. Thus, the confirmation of innovative and more precise noninvasive biomarkers holds promise for the detection of PTC, which may decrease the number of unnecessary thyroid lobectomies. In this work, using the droplet digital PCR (ddPCR) method, we have analyzed the level of five miRNAs (let-7a, let-7c, let-7d, let-7f, and let-7i) in the plasma of patients with PTC and compared them with those of a healthy control group to investigate whether miRNAs also have value in the management of PTC. Levels of four miRNAs, namely let-7a, let-7c, let-7d, and let-7f, were significantly higher in PTC patients than healthy controls. Thus, the analysis of circulating let-7 can be a useful tool and support the currently used methods for PTC diagnosis. However, our observation requires further research on a larger patient group. View Full-Text
Keywords: PTC; miRNA; let-7; ddPCR; diagnostics PTC; miRNA; let-7; ddPCR; diagnostics
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Perdas, E.; Stawski, R.; Kaczka, K.; Zubrzycka, M. Analysis of Let-7 Family miRNA in Plasma as Potential Predictive Biomarkers of Diagnosis for Papillary Thyroid Cancer. Diagnostics 2020, 10, 130.

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