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Volume 10
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10.3390/diagnostics10020124
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Article

Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population

by
Masahiko Ayaki
1,2,*,
Kazuno Negishi
2,*,
Kenya Yuki
2,
Motoko Kawashima
2,
Miki Uchino
2 and
Kazuo Tsubota
2
1
Otake Clinic Moon View Eye Center, Yamato 2420001, Japan
2
Department of Ophthalmology, Keio University School of Medicine, Tokyo 1608582, Japan
*
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(2), 124; https://doi.org/10.3390/diagnostics10020124
Received: 22 January 2020 / Revised: 17 February 2020 / Accepted: 22 February 2020 / Published: 24 February 2020
(This article belongs to the Special Issue Dry Eye and Ocular Surface Disorders)
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Abstract

Purpose: To evaluate seasonal variation in intraocular pressure (IOP) with and without short tear break-up time (SBUT, BUT ≤5 s) since dry eye and IOP are known to have seasonal variation. Methods: This study enrolled 176 patients who visited one of six eye clinics, in Japan, four times for IOP measurement, in every season. The mean patient age was 67.9 years, including 79 males. Participants were divided into four groups based on the presence of glaucoma and/or SBUT and we compared the seasonal variation in IOP (winter and summer) among the four groups. Results: The IOP (mmHg) in winter and summer, respectively, was 12.8 ± 3.7 and 12.8 ± 3.1 for non-glaucoma patients without SBUT (n = 47, p = 0.964), 14.8 ± 3.4 and 13.3 ± 3.4 for non-glaucoma patients with SBUT (n = 57, p < 0.001), 14.3 ± 3.2 and 14.1 ± 3.4 for glaucoma patients without SBUT (n = 36, p = 0.489), and 13.3 ± 3.0 and 11.6 ± 2.9 for glaucoma with SBUT (n = 36, p < 0.001). Seasonal variation was largest across the seasons in the glaucoma with the SBUT group, and the magnitude of seasonal variation correlated with BUT (β = 0.228, p = 0.003). Conclusions: Seasonal variation tended to be larger in patients with SBUT than those without SBUT. View Full-Text
Keywords: dry eye; tear break-up time; intraocular pressure; seasonality dry eye; tear break-up time; intraocular pressure; seasonality
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MDPI and ACS Style

Ayaki, M.; Negishi, K.; Yuki, K.; Kawashima, M.; Uchino, M.; Tsubota, K. Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population. Diagnostics 2020, 10, 124. https://doi.org/10.3390/diagnostics10020124

AMA Style

Ayaki M, Negishi K, Yuki K, Kawashima M, Uchino M, Tsubota K. Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population. Diagnostics. 2020; 10(2):124. https://doi.org/10.3390/diagnostics10020124

Chicago/Turabian Style

Ayaki, Masahiko, Kazuno Negishi, Kenya Yuki, Motoko Kawashima, Miki Uchino, and Kazuo Tsubota. 2020. "Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population" Diagnostics 10, no. 2: 124. https://doi.org/10.3390/diagnostics10020124

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