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Peer-Review Record

Multiple Testing, Cut-Point Optimization, and Signs of Publication Bias in Prognostic FDG–PET Imaging Studies of Head and Neck and Lung Cancer: A Review and Meta-Analysis

Diagnostics 2020, 10(12), 1030; https://doi.org/10.3390/diagnostics10121030
by Malene M. Clausen 1,2,*, Ivan R. Vogelius 2,3, Andreas Kjær 1 and Søren M. Bentzen 3
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Diagnostics 2020, 10(12), 1030; https://doi.org/10.3390/diagnostics10121030
Submission received: 19 October 2020 / Revised: 25 November 2020 / Accepted: 29 November 2020 / Published: 1 December 2020
(This article belongs to the Section Medical Imaging and Theranostics)

Round 1

Reviewer 1 Report

Extensive and well designed review paper. As the authors describes this field suffers from many misleading inforamtion. Please provide figure 4 in form with visible plots. I would recommend additional analyisis focusing on study comparison based on the  tumor grade and FDG uptake relation analysis.

Author Response

Figure 4 has been updated in order to make the plots more visible. 

Comparison based on tumor grade and FDG uptake could be an interesting analysis to make, however, these data are not available from the included studies. 

Reviewer 2 Report

Dear authors,

I thank you for your very interesting manuscript. Please find my comments here under.

Line 42-43-44: Several studies have investigated the prognostic value of FDG PET, and dose escalation to PET positive areas within the tumor is one of the potential strategies for increasing effect of radiotherapy : please mark some references

Line 226 Figure 4: plots A & B in figure 4 are not completed (Bubbles missing)

Author Response

References has been added (line 42-44).

Figure 4 has been updated, and the bobbles are now in colours for a better visualisation. 

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