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Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis

1
Department of Physiotherapy, Faculty of Health, Camilo José Cela University, Villanueva de la Cañada, 28692 Madrid, Spain
2
Department of Sport Sciences, Faculty of Health, Camilo José Cela University, Villanueva de la Cañada, 28692 Madrid, Spain
3
Department of Nursing, Faculty of Health, Camilo José Cela University, Villanueva de la Cañada, 28692 Madrid, Spain
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(11), 922; https://doi.org/10.3390/diagnostics10110922
Received: 30 September 2020 / Revised: 3 November 2020 / Accepted: 3 November 2020 / Published: 9 November 2020
(This article belongs to the Section Point-of-Care Diagnostics and Devices)
This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia. View Full-Text
Keywords: fibromyalgia; chronic pain; cortisol; treatment; meta-analysis fibromyalgia; chronic pain; cortisol; treatment; meta-analysis
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MDPI and ACS Style

Úbeda-D’Ocasar, E.; Jiménez Díaz-Benito, V.; Gallego-Sendarrubias, G.M.; Valera-Calero, J.A.; Vicario-Merino, Á.; Hervás-Pérez, J.P. Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis. Diagnostics 2020, 10, 922. https://doi.org/10.3390/diagnostics10110922

AMA Style

Úbeda-D’Ocasar E, Jiménez Díaz-Benito V, Gallego-Sendarrubias GM, Valera-Calero JA, Vicario-Merino Á, Hervás-Pérez JP. Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis. Diagnostics. 2020; 10(11):922. https://doi.org/10.3390/diagnostics10110922

Chicago/Turabian Style

Úbeda-D’Ocasar, Edurne, Victor Jiménez Díaz-Benito, Gracia M. Gallego-Sendarrubias, Juan A. Valera-Calero, Ángel Vicario-Merino, and Juan P. Hervás-Pérez 2020. "Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis" Diagnostics 10, no. 11: 922. https://doi.org/10.3390/diagnostics10110922

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