Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Ethics
2.3. Image Acquisition
2.4. Image Processing and Interpretation
2.4.1. Attenuation Correction
2.4.2. Alignment
2.5. Statistics
3. Results
3.1. Demographics and Clinical Characteristics
3.2. Studies in Donors before Nephrectomy and in Transplant Recipients
4. Discussion
4.1. Strengths and Limitations
4.2. Future
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
Appendix A
Attenuation Correction
References
- Converse, R.L.; Jacobsen, T.N.; Toto, R.D.; Jost, C.M.; Cosentino, F.; Fouad-Tarazi, F.; Victor, R.G. Sympathetic Overactivity in Patients with Chronic Renal Failure. N. Engl. J. Med. 1992, 327, 1912–1918. [Google Scholar] [CrossRef] [PubMed]
- Hausberg, M.; Kosch, M.; Harmelink, P.; Barenbrock, M.; Hohage, H.; Herne, K.K.; Dietl, K.H.; Rahn, K.H. Sympathetic Nerve Activity in End-Stage Renal Disease. Circulation 2002, 106, 1974–1979. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Grassi, G.; Quarti-Trevano, F.; Seravalle, G.; Arenare, F.; Volpe, M.; Furiani, S.; Dell’Oro, R.; Mancia, G. Early Sympathetic Activation in the Initial Clinical Stages of Chronic Renal Failure. Hypertension 2011, 57, 846–851. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hansen, J.M.; Abildgaard, U.; Fogh-Andersen, N.; Kanstrup, I.-L.; Bratholm, P.; Plum, I.; Strandgaard, S. The Transplanted Human Kidney Does Not Achieve Functional Reinnervation. Clin. Sci. 1994, 87, 13–20. [Google Scholar] [CrossRef] [PubMed]
- Norvell, J.E.; Weitsen, H.A.; Sheppek, C.G. The intrinsic innervation of human renal homotransplants. Transplantation 1970, 9, 168–176. [Google Scholar] [PubMed]
- Gazdar, A.F.; Dammin, G.J. Neural Degeneration and Regeneration in Human Renal Transplants. N. Engl. J. Med. 1970, 283, 222–224. [Google Scholar] [CrossRef]
- Krum, H.; Schlaich, M.P.; Whitbourn, R.; Sobotka, P.A.; Sadowski, J.; Bartus, K.; Kapelak, B.; Walton, A.; Sievert, H.; Thambar, S.; et al. Catheter-based renal sympathetic denervation for resistant hypertension: A multicentre safety and proof-of-principle cohort study. Lancet 2009, 373, 1275–1281. [Google Scholar] [CrossRef]
- Esler, M.; Krum, H.; Sobotka, P.A.; Schlaich, M.P.; Schmieder, R.E.; Böhm, M.; Mahfoud, F.; Sievert, H.; Wunderlich, N.; Rump, L.C.; et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial. Lancet 2010, 376, 1903–1909. [Google Scholar] [CrossRef]
- Bhatt, D.; Kandzari, D.; O’Neill, W. A Controlled Trial of Renal Denervation for Resistant Hypertension. J. Vasc. Surg. 2014, 60, 266. [Google Scholar] [CrossRef] [Green Version]
- DiBona, G.F. The functions of the renal nerves. Rev. Physiol. Biochem. Pharmacol. 1982, 94, 75–181. [Google Scholar] [CrossRef]
- DiBona, G.F. Sympathetic nervous system and the kidney in hypertension. Curr. Opin. Nephrol. Hypertens. 2002, 11, 197–200. [Google Scholar] [CrossRef] [PubMed]
- Sisson, J.C.; Wieland, D.M. Radiolabeled meta-iodobenzylguanidine: Pharmacology and clinical studies. Am. J. Physiol. Imaging 1986, 1, 96–103. [Google Scholar] [PubMed]
- Wieland, D.M.; Brown, L.E.; Rogers, W.L.; Worthington, K.C.; Wu, J.L.; Clinthorne, N.H.; Otto, C.A.; Swanson, D.P.; Beierwaltes, W.H. Myocardial imaging with a radioiodinated norepinephrine storage analog. J. Nucl. Med. 1981, 22, 22–31. [Google Scholar] [PubMed]
- Torres, G.E.; Gainetdinov, R.R.; Caron, M.G. Plasma membrane monoamine transporters: Structure, regulation and function. Nat. Rev. Neurosci. 2003, 4, 13–25. [Google Scholar] [CrossRef] [PubMed]
- Kline, R.C.; Swanson, D.P.; Wieland, D.M.; Thrall, J.H.; Gross, M.D.; Pitt, B.; Beierwaltes, W.H. Myocardial imaging in man with I-123 meta-iodobenzylguanidine. J. Nucl. Med. 1981, 22, 129–132. [Google Scholar]
- Blake, G.; Lewington, V.; Zivanovic, M.; Ackery, D. Glomerular filtration rate and the kinetics of 123I-metaiodobenzylguanidine. Eur. J. Nucl. Med. Mol. Imaging 1989, 15, 618–623. [Google Scholar] [CrossRef] [PubMed]
- Iwase, S. Clinical Assessment of the Autonomic Nervous System; Springer: New York, NY, USA; Berlin/Heidelberg, Germany, 2016. [Google Scholar]
- Ito, S.; Kusuhara, H.; Yokochi, M.; Toyoshima, J.; Inoue, K.; Yuasa, H.; Sugiyama, Y. Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney. J. Pharmacol. Exp. Ther. 2011, 340, 393–403. [Google Scholar] [CrossRef] [Green Version]
- Wiseman, G.A.; Pacak, K.; O’Dorisio, M.; Neumann, D.R.; Waxman, A.D.; Mankoff, D.A.; Heiba, S.I.; Serafini, A.N.; Tumeh, S.S.; Khutoryansky, N.; et al. Usefulness of 123I-MIBG scintigraphy in the evaluation of patients with known or suspected primary or metastatic pheochromocytoma or paraganglioma: Results from a prospective multicenter trial. J. Nucl. Med. 2009, 50, 1448–1454. [Google Scholar] [CrossRef] [Green Version]
- Jacobson, A.F.; Senior, R.; Cerqueira, M.D.; Wong, N.D.; Thomas, G.S.; Lopez, V.A.; Agostini, D.; Weiland, F.; Chandna, H.; Narula, J.; et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J. Am. Coll. Cardiol. 2010, 55, 2212–2221. [Google Scholar] [CrossRef] [Green Version]
- De Marco, T.; Dae, M.; Yuen-Green, M.S.; Kumar, S.; Sudhir, K.; Keith, F.; Amidon, T.M.; Rifkin, C.; Klinski, C.; Lau, D.; et al. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: Evidence for late reinnervation. J. Am. Coll. Cardiol. 1995, 25, 927–931. [Google Scholar] [CrossRef] [Green Version]
- Liu, B.; Codreanu, I.; Yang, J.; Servaes, S.; Zhuang, H. Diffuse Elevated MIBG Activity in the Renal Parenchyma Caused by Compromised Renal Blood Flow. Clin. Nucl. Med. 2014, 39, 1005–1008. [Google Scholar] [CrossRef] [PubMed]
- Jordan, A.; Seltzer, M.; Siegel, A. 123I MIBG Appearance of Severe Renal Artery Stenosis. Clin. Nucl. Med. 2014, 39, 1003–1004. [Google Scholar] [CrossRef] [PubMed]
- Dobrowolski, L.C.; Verberne, H.J.; van den Born, B.-J.H.; Ten Berge, I.J.; Bemelman, F.J.; Krediet, C.T.P. Kidney Transplant 123I-mIBG Scintigraphy and Functional Sympathetic Reinnervation. Am. J. Kidney Dis. 2015, 66, 543–544. [Google Scholar] [CrossRef] [PubMed]
- Dobrowolski, L.C.; Eeftinck, D.W.S.; Idu, M.M.; van den Born, B.-J.H.; Verberne, H.J. Renal 123I-MIBG Scintigraphy Before and After Kidney Autotransplantation. Clin. Nucl. Med. 2015, 40, 810–811. [Google Scholar] [CrossRef]
- Dobrowolski, L.; Schattenkerk, D.E.; Krediet, C.; Van Brussel, P.; Reekers, J.; van den Born, B.; Verberne, H. 4A.08: Assessing Modulations in Sympathetic Nerve Activity after Renal Sympathetic Denervation Using Renal 123i-Mibg Scintigraphy. J. Hypertens. 2015, 33 (Suppl. 1), e51. [Google Scholar] [CrossRef]
- Menorca, R.M.; Fussell, T.S.; Elfar, J.C. Nerve physiology: Mechanisms of injury and recovery. Hand Clin. 2013, 29, 317–330. [Google Scholar] [CrossRef] [Green Version]
- Wang, J.T.; Medress, Z.A.; Barres, B.A. Axon degeneration: Molecular mechanisms of a self-destruction pathway. J. Cell Biol. 2012, 196, 7–18. [Google Scholar] [CrossRef] [Green Version]
- Verberne, H.J.; Feenstra, C.; De Jong, W.M.; Somsen, G.A.; Van Eck-Smit, B.L.F.; Sokole, E.B.; Eck-Smit, B.L.F. Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: A phantom study. Eur. J. Nucl. Med. Mol. Imaging 2005, 32, 1100–1107. [Google Scholar] [CrossRef]
- Dobbeleir, A.A.; Hambÿe, A.-S.E.; Franken, P.R. Influence of high-energy photons on the spectrum of iodine-123 with low- and medium-energy collimators: Consequences for imaging with 123I-labelled compounds in clinical practice. Eur. J. Nucl. Med. Mol. Imaging 1999, 26, 655–658. [Google Scholar] [CrossRef]
- Kjaer, M.; Jurlander, J.; Keiding, S.; Galbo, H.; Kirkegaard, P.; Hage, E. No reinnervation of hepatic sympathetic nerves after liver transplantation in human subjects. J. Hepatol. 1994, 20, 97–100. [Google Scholar] [CrossRef]
- Bravo, P.E.; Lautamäki, R.; Carter, D.; Holt, D.P.; Nekolla, S.G.; Dannals, R.F.; Russell, S.D.; Bengel, F.M. Mechanistic Insights into Sympathetic Neuronal RegenerationCLINICAL PERSPECTIVE. Circ. Cardiovasc. Imaging 2015, 8, e003507. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bai, C.; Shao, L.; Da Silva, A.; Zhao, Z. A generalized model for the conversion from ct numbers to linear attenuation coefficients. IEEE Trans. Nucl. Sci. 2003, 50, 1510–1515. [Google Scholar] [CrossRef]
- Rhee, D.J.; Kim, S.-W.; Jeong, D.H.; Moon, Y.M.; Kim, J.K. Effects of the difference in tube voltage of the CT scanner on dose calculation. J. Korean Phys. Soc. 2015, 67, 123–128. [Google Scholar] [CrossRef]
- Hubbell, J.H.; Seltzer, S.M. Tables of X-ray Mass Attenuation Coefficients and Mass Energy-Absorption Coefficients from 1 keV to 20 MeV for Elements Z = 1 to 92 and 48 Additional Substances of Dosimetric Interest. Available online: http://physics.nist.gov/PhysRefData/XrayMassCoef/tab4.html (accessed on 20 August 2015).
Donors | Recipients | |
---|---|---|
Age, years (SD) | 52 (13) | 47 (16) |
Gender, female, n (%) | 4 (45) | 5 (36) |
51Cr-EDTA clearance, ml/min (SD) | 106 (28) | * |
Office blood pressure, systolic/diastolic, mmHg (SD) | 135 (15)/83 (10) | 139 (25)/82 (15) |
Diabetes, n (%) | 0 (0) | 3 (27) |
Hypertension, n (%) | 0 (0) | 3 (27) |
Baseline n = 11 (SD) | 1 Month n = 11 (SD) | 3 Months n = 10 (SD) | 6 Months n = 11 (SD) | Change between Baseline and 6 Months Mean (95% CI) | p Value | |
---|---|---|---|---|---|---|
Relative Ratio | ||||||
15 min Kidney/Background | 6.8 (1.8) | 5.0 (1.4) | 5.5 (1.4) | 4.7 (1.5) | −2.3 (−3.4 to −1.2) | 0.0010 * |
1 h Kidney/Background | 4.8 (0.9) | 3.3 (1.0) | 3.6 (0.8) | 3.1 (0.6) | −1.8 (−2.7 to −0.9) | 0.0012 * |
2 h Kidney/Background | 4.5 (0.6) | 3.0 (0.5) | 3.1 (0.5) | 2.7 (0.5) | −1.9 (−2.6 to −1.2) | 0.0002 * |
4 h Kidney/Background | 4.0 (0.4) | 2.7 (0.4) | 2.7 (0.5) | 2.5 (0.4) | −1.5 (−2.0 to −1.0) | <0.0001 * |
Washout Rate | ||||||
15 min to 1 h (%/hour) | 50.1 (42.7) | 42.6 (25.5) | 50.9 (26.2) | 31.3 (33.5) | −16.9 (−38.7 to 4.8) | 0.1109 |
15 min to 2 h (%/hour) | 26.8 (21.8) | 23.4 (14.0) | 31.0 (10.4) | 27.5 (12.8) | −0.7 (−14.8 to 13.4) | 0.9067 |
15 min to 4 h (%/hour) | 16.3 (9.4) | 15.2 (4.2) | 15.5 (5.7) | 13.7 (7.2) | −3.3 (−9.5 to 2.7) | 0.2436 |
1 to 2 h (%/hour) | 9.6 (9.8) | 7.3 (28.6) | 16.8 (14.8) | 22.7 (20.9) | 10.1 (−10.0 to 30.3) | 0.2731 |
2 to 4 h (%/hour) | 9.4 (5.0) | 7.8 (11.9) | 1.5 (9.6) | 1.8 (6.0) | −8.3 (−15.1 to −1.4) | 0.024 * |
Washout | ||||||
Washout 15 min to 4 h (%) | 43.3 (14.7) | 42.8 (9.1) | 42.7 (11.8) | 38.1 (18.0) | −6.7 (−19.8 to 6.4) | 0.2800 |
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Rasmussen, T.; de Nijs, R.; Kjær Olsen, L.; Kamper, A.-L.; Evi Bang, L.; Frimodt-Møller, M.; Kelbæk, H.; Schwartz Sørensen, S.; Kjær, A.; Feldt-Rasmussen, B.; et al. Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation. Diagnostics 2020, 10, 802. https://doi.org/10.3390/diagnostics10100802
Rasmussen T, de Nijs R, Kjær Olsen L, Kamper A-L, Evi Bang L, Frimodt-Møller M, Kelbæk H, Schwartz Sørensen S, Kjær A, Feldt-Rasmussen B, et al. Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation. Diagnostics. 2020; 10(10):802. https://doi.org/10.3390/diagnostics10100802
Chicago/Turabian StyleRasmussen, Thomas, Robin de Nijs, Lene Kjær Olsen, Anne-Lise Kamper, Lia Evi Bang, Marie Frimodt-Møller, Henning Kelbæk, Søren Schwartz Sørensen, Andreas Kjær, Bo Feldt-Rasmussen, and et al. 2020. "Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation" Diagnostics 10, no. 10: 802. https://doi.org/10.3390/diagnostics10100802