Coexistence of Growth Hormone Deficiency and Pituitary Microadenoma in a Child with Unique Mosaic Turner Syndrome: A Case Report and Literature Review
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Case in This Study | Yu et al. [12] | Yu et al. [12] | Brook et al. [13] | Efstathiadou et al. [14] | Gallicchino et al. [15] | Jin et al. [16] | |
---|---|---|---|---|---|---|---|
Age at diagnosis (y) | 12.3 | 8.9 | 12.3 | 9.1 | 30 | 11 | 11 |
Turner syndrome | 12.3 | 7.5 | 12.3 | 9.6 | 17 | 12 | 11 |
GH deficiency | |||||||
Height (SDS) at diagnosis | −3.4 | −1.89 | −1.72 † | −3.6 | −2.35 | −4.2 | −3.69 |
Turner syndrome | −3.4 | −2.30 | −1.72 † | NA | −6.0 | −4.9 | −3.69 |
GH deficiency | |||||||
Karyotype | 46,X,r(X)/45,X/46,X,psu dic r(X;X) | 45,X/45,X+mar | 45,X/46,XX | 45,X | 45,X | 45,X/46,XX | 45,X |
Peak GH on GH provocation test (ng/mL) | 3.63 | 6.17 | 7.38 | 6.1 | 4.65 | 0.14 | <5 |
Other pituitary hormone deficiencies | ACTH | None | None | None | TSH, gonadotropin | TSH, gonadotropin | None |
Associated conditions | Subclinical hypothyroidism, pituitary microadenoma | Partial empty sella, horseshoe kidney | None | None | None | Empty sella | Chronic lymphocytic thyroiditis |
Case in This Study | Yeh et al. [8] | Bolanowski et al. [18] | Gaspar et al. [19] | Mermilliod et al. [20] | Weibel et al. [21] | Dotsch et al. [22] | Willemse et al. [23] | Yamazaki et al. [24] | Gelfand et al. [25] | |
---|---|---|---|---|---|---|---|---|---|---|
Age at TS diagnosis (yr) | 13 | 16 | 10 | 16 | 16 | 43 | 12 | 19 | 33 | 26 |
Age at pituitary disease diagnosis (yr) | 13 | 16 | 33 | 25 | 18 | 43 | 19 | 26 | 33 | 29 |
Karyotype | 46,X,r(X)/45,X/46,X,psu dic r(X;X) | 45,X | 45,X/46,X,i(X) (q10) | 45,X/46,XX | 45,X | 45,X/46,XX/47,XXX | 45,X/46,XX | 45,X | 47,XXX/45,X/46,XX | 45,X/47,XXX |
Symptoms or labs related to pituitary disease | Short stature | Headache, vomiting, cranial nerve IV palsy | Facial changes, increased hand/foot size | Secondary amenorrhea, galactorrhea | Hypogonado-tropic hypogonadism | Unexpected normalization of FSH level | Secondary amenorrhea, hyperprolactinemia | Change in appearance, enlarged feet | Dysphagia due to soft palate edema, enlarged hands/feet | Weight gain, ankle edema, acne, hirsutism |
Pituitary hormone abnormalities | Deficiency in GH, ACTH | Deficiency in GnRH | GH excess | Prolactin excess | Deficiency in GnRH | Deficiency in GnRH | Prolactin excess | GH excess | GH excess | Cortisol excess |
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Park, E.G.; Kim, E.-J.; Kim, E.-J.; Kim, H.-Y.; Kim, S.-H.; Yang, A. Coexistence of Growth Hormone Deficiency and Pituitary Microadenoma in a Child with Unique Mosaic Turner Syndrome: A Case Report and Literature Review. Diagnostics 2020, 10, 783. https://doi.org/10.3390/diagnostics10100783
Park EG, Kim E-J, Kim E-J, Kim H-Y, Kim S-H, Yang A. Coexistence of Growth Hormone Deficiency and Pituitary Microadenoma in a Child with Unique Mosaic Turner Syndrome: A Case Report and Literature Review. Diagnostics. 2020; 10(10):783. https://doi.org/10.3390/diagnostics10100783
Chicago/Turabian StylePark, Eu Gene, Eun-Jung Kim, Eun-Jee Kim, Hyun-Young Kim, Sun-Hee Kim, and Aram Yang. 2020. "Coexistence of Growth Hormone Deficiency and Pituitary Microadenoma in a Child with Unique Mosaic Turner Syndrome: A Case Report and Literature Review" Diagnostics 10, no. 10: 783. https://doi.org/10.3390/diagnostics10100783