Phosphates as Energy Sources to Expand Metabolic Networks
AbstractPhosphates are essential for modern metabolisms. A recent study reported a phosphate-free metabolic network and suggested that thioesters, rather than phosphates, could alleviate thermodynamic bottlenecks of network expansion. As a result, it was considered that a phosphorus-independent metabolism could exist before the phosphate-based genetic coding system. To explore the origin of phosphorus-dependent metabolism, the present study constructs a protometabolic network that contains phosphates prebiotically available using computational systems biology approaches. It is found that some primitive phosphorylated intermediates could greatly alleviate thermodynamic bottlenecks of network expansion. Moreover, the phosphorus-dependent metabolic network exhibits several ancient features. Taken together, it is concluded that phosphates played a role as important as that of thioesters during the origin and evolution of metabolism. Both phosphorus and sulfur are speculated to be critical to the origin of life. View Full-Text
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Tian, T.; Chu, X.-Y.; Yang, Y.; Zhang, X.; Liu, Y.-M.; Gao, J.; Ma, B.-G.; Zhang, H.-Y. Phosphates as Energy Sources to Expand Metabolic Networks. Life 2019, 9, 43.
Tian T, Chu X-Y, Yang Y, Zhang X, Liu Y-M, Gao J, Ma B-G, Zhang H-Y. Phosphates as Energy Sources to Expand Metabolic Networks. Life. 2019; 9(2):43.Chicago/Turabian Style
Tian, Tian; Chu, Xin-Yi; Yang, Yi; Zhang, Xuan; Liu, Ye-Mao; Gao, Jun; Ma, Bin-Guang; Zhang, Hong-Yu. 2019. "Phosphates as Energy Sources to Expand Metabolic Networks." Life 9, no. 2: 43.
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