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Peptidyl Transferase Center and the Emergence of the Translation System

1
Laboratório de Genética Evolutiva Paulo Leminsk, Departamento de Biologia Molecular, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil
2
Departamento de Informática, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil
3
Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 CDMX, Mexico
*
Authors to whom correspondence should be addressed.
Academic Editors: Sohan Jheeta and David Deamer
Received: 14 March 2017 / Revised: 5 April 2017 / Accepted: 17 April 2017 / Published: 25 April 2017
(This article belongs to the Special Issue The Landscape of the Emergence of Life)
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Abstract

In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus. Docking experiments between the ancestral PTC and tRNAs suggest that in the origin of the translation system, the PTC functioned as an adhesion center for tRNA molecules. The approximation of tRNAs charged with amino acids to the PTC permitted peptide synthesis without the need of a genetic code. View Full-Text
Keywords: PTC; evolution; translation; origins PTC; evolution; translation; origins
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Torres de Farias, S.; Gaudêncio Rêgo, T.; José, M.V. Peptidyl Transferase Center and the Emergence of the Translation System. Life 2017, 7, 21.

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