Next Article in Journal
Modes of Fatty Acid Desaturation in Cyanobacteria: An Update
Next Article in Special Issue
Haloferax volcanii, as a Novel Tool for Producing Mammalian Olfactory Receptors Embedded in Archaeal Lipid Bilayer
Previous Article in Journal / Special Issue
The Adaptive Immune System of Haloferax volcanii
Open AccessReview

A Prokaryotic Twist on Argonaute Function

1
Institute of Molecular Medicine, Universitätsklinikum Schleswig-Holstein, University of Lübeck, 23538 Lübeck, Germany
2
Physikalische und Theoretische Chemie-NanoBioSciences, Technische Universität Braunschweig, Hans-Sommer-Strasse 10, 38106 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Hans-Peter Klenk, Michael W. W. Adams and Roger A. Garrett
Life 2015, 5(1), 538-553; https://doi.org/10.3390/life5010538
Received: 21 December 2014 / Accepted: 5 February 2015 / Published: 16 February 2015
(This article belongs to the Special Issue Archaea: Evolution, Physiology, and Molecular Biology)
Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression. Despite the mechanistic and structural similarities between archaeal, bacterial and eukaryotic Argonaute proteins, the biological function of bacterial and archaeal Argonautes has remained elusive. This review discusses new findings in the field that shed light on the structure and function of Argonaute. We especially focus on archaeal Argonautes when discussing the details of the structural and dynamic features in Argonaute that promote substrate recognition and cleavage, thereby revealing differences and similarities in Argonaute biology. View Full-Text
Keywords: Argonaute; archaeal; interference, guide strand Argonaute; archaeal; interference, guide strand
Show Figures

Figure 1

MDPI and ACS Style

Willkomm, S.; Zander, A.; Gust, A.; Grohmann, D. A Prokaryotic Twist on Argonaute Function. Life 2015, 5, 538-553.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop