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Article

Genetic Association Study of IL23R and IL12B Polymorphisms with Psoriasis in a Romanian Population

by
Alessandra-Madalina Matei-Man
1,
Ildiko-Orsolya Gaal
2,
Andreea Catana
2,
Stefan Vesa
3,*,
Simona Senila
1,
Elisabeta Candrea
1,
Meda Orasan
4,
Alexandra Puskas
5,
Ana Calina Man
6 and
Teodora Mocan
7
1
Dermatology Department, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, Romania
2
Department of Medical Genetics, “Iuliu Hațieganu” University of Medicine and Pharmacy, Pasteur Street 6, 400349 Cluj-Napoca, Romania
3
Department 2 Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
4
Physiopathology Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, Romania
5
Independent Researcher, 1021 Budapest, Hungary
6
Life Sciences, Biotechnology Department, Harvard Extension School, Cambridge, MA 02138, USA
7
Physiology Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400126 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Life 2026, 16(4), 574; https://doi.org/10.3390/life16040574
Submission received: 5 March 2026 / Revised: 26 March 2026 / Accepted: 30 March 2026 / Published: 1 April 2026
(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition)
Versions Notes

Abstract

Background: Psoriasis is a chronic immune-mediated inflammatory disease with a strong genetic basis, driven in part by the dysregulation of the IL-23/Th17 signaling axis. Variants in the IL23R and IL12B genes have been associated with psoriasis susceptibility; however, data from Eastern European populations remains scarce. Objective: We aimed to evaluate the link between IL23R rs11209026 and IL12B rs3213094 polymorphisms and psoriasis susceptibility in a multi-center, Romanian cohort. Methods: We performed a multi-center case–control study including adult patients with clinically and histopathologically confirmed moderate-to-severe psoriasis undergoing biological therapy and controls without autoimmune or chronic inflammatory diseases. Genotyping was performed using TaqMan SNP assays. Associations were analyzed under a dominant genetic model. Results: A significant association was observed between IL23R rs11209026 polymorphism and psoriasis susceptibility. Carriers of the A allele (AA+GA) showed reduced odds of psoriasis compared with the GG homozygotes, emphasizing the protective effect of this specific variant. No significant association was identified for IL12B rs3213094 polymorphism. Conclusions: Our findings support the protective association of IL23R rs11209026 A allele with psoriasis in a Romanian Eastern European population and emphasize the importance of the IL-23 pathway in disease pathogenesis. Alcohol consumption was independently associated with increased risk of psoriasis. Further studies are justified to explore potential pharmacogenetic implications.
Keywords: psoriasis; IL23R; rs11209026; IL12B; genetic polymorphism; IL-23/Th17 axis psoriasis; IL23R; rs11209026; IL12B; genetic polymorphism; IL-23/Th17 axis

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MDPI and ACS Style

Matei-Man, A.-M.; Gaal, I.-O.; Catana, A.; Vesa, S.; Senila, S.; Candrea, E.; Orasan, M.; Puskas, A.; Man, A.C.; Mocan, T. Genetic Association Study of IL23R and IL12B Polymorphisms with Psoriasis in a Romanian Population. Life 2026, 16, 574. https://doi.org/10.3390/life16040574

AMA Style

Matei-Man A-M, Gaal I-O, Catana A, Vesa S, Senila S, Candrea E, Orasan M, Puskas A, Man AC, Mocan T. Genetic Association Study of IL23R and IL12B Polymorphisms with Psoriasis in a Romanian Population. Life. 2026; 16(4):574. https://doi.org/10.3390/life16040574

Chicago/Turabian Style

Matei-Man, Alessandra-Madalina, Ildiko-Orsolya Gaal, Andreea Catana, Stefan Vesa, Simona Senila, Elisabeta Candrea, Meda Orasan, Alexandra Puskas, Ana Calina Man, and Teodora Mocan. 2026. "Genetic Association Study of IL23R and IL12B Polymorphisms with Psoriasis in a Romanian Population" Life 16, no. 4: 574. https://doi.org/10.3390/life16040574

APA Style

Matei-Man, A.-M., Gaal, I.-O., Catana, A., Vesa, S., Senila, S., Candrea, E., Orasan, M., Puskas, A., Man, A. C., & Mocan, T. (2026). Genetic Association Study of IL23R and IL12B Polymorphisms with Psoriasis in a Romanian Population. Life, 16(4), 574. https://doi.org/10.3390/life16040574

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