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Article

The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome

by
Mihaela-Andreea Podeanu
1,2,
Ștefănița Bianca Vintilescu
2,*,
Claudiu Marinel Ionele
3,*,
Raluca Elena Sandu
4,
Carmen Elena Niculescu
2,
Mirela-Marinela Florescu
5 and
Mioara Desdemona Stepan
2
1
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Infant Care, Pediatrics and Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
5
Department of Pathology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Authors to whom correspondence should be addressed.
Life 2024, 14(9), 1206; https://doi.org/10.3390/life14091206
Submission received: 28 August 2024 / Revised: 17 September 2024 / Accepted: 19 September 2024 / Published: 23 September 2024
(This article belongs to the Special Issue Obesity: Precision Diagnosis, Personalised Treatment, Patient Engagement and Recognition as a Disease)
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Abstract

Obesity is linked to the increasing prevalence of metabolic syndrome (MetS), even among the pediatric population. Some inflammatory and cardioembolic indexes derived from routine laboratory tests have captivated the attention of the medical community. Objectives: The aim of our study was to evaluate whether these markers are effective in distinguishing varying degrees of obesity and MetS in children and adolescents. Methods: We conducted a retrospective study. A total of 71 children and adolescents, aged between 6 and 16, were included in the study. Among them, 5 were overweight, 35 had obesity, and 31 had severe obesity. According to the NCEP ATP III criteria, 32 individuals had Metabolic Syndrome (MetS), while 39 did not have MetS. Results: The MetS positive group had higher values of TG/HDL-C (p < 0.001), TC/HDL-C (p < 0.001), MHR (p = 0.015), LHR (p = 0.001), NHR (p = 0.001), atherogenic index of plasma (p < 0.001), and PHR (p < 0.001). ESR, NLR, PLR, and SII did not progressively increase with the number of MetS criteria. The ROC curve analysis demonstrated that markers such as TG/HDL-C, the atherogenic index of plasma, TC/HDL-C, LHR, NHR, and PHR were effective in identifying MetS in children and adolescents with obesity. Conclusions: In conclusion, we determined that some novel inflammatory and cardioembolic indexes are useful in assessing MetS and obesity in children and adolescents.
Keywords: obesity; metabolic syndrome; inflammation; inflammatory indexes; cardioembolic indexes; children; adolescents obesity; metabolic syndrome; inflammation; inflammatory indexes; cardioembolic indexes; children; adolescents

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MDPI and ACS Style

Podeanu, M.-A.; Vintilescu, Ș.B.; Ionele, C.M.; Sandu, R.E.; Niculescu, C.E.; Florescu, M.-M.; Stepan, M.D. The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome. Life 2024, 14, 1206. https://doi.org/10.3390/life14091206

AMA Style

Podeanu M-A, Vintilescu ȘB, Ionele CM, Sandu RE, Niculescu CE, Florescu M-M, Stepan MD. The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome. Life. 2024; 14(9):1206. https://doi.org/10.3390/life14091206

Chicago/Turabian Style

Podeanu, Mihaela-Andreea, Ștefănița Bianca Vintilescu, Claudiu Marinel Ionele, Raluca Elena Sandu, Carmen Elena Niculescu, Mirela-Marinela Florescu, and Mioara Desdemona Stepan. 2024. "The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome" Life 14, no. 9: 1206. https://doi.org/10.3390/life14091206

APA Style

Podeanu, M.-A., Vintilescu, Ș. B., Ionele, C. M., Sandu, R. E., Niculescu, C. E., Florescu, M.-M., & Stepan, M. D. (2024). The Role of Paraclinical Investigations in Detecting Inflammation in Children and Adolescents with Obesity and Metabolic Syndrome. Life, 14(9), 1206. https://doi.org/10.3390/life14091206

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