Fecal Microbiota Transplantation for Weight and Glycemic Control of Obesity as Well as the Associated Metabolic Diseases: Meta-Analysis and Comprehensive Assessment
Abstract
:1. Introduction
2. Approaches
2.1. Criteria for Including and Excluding Literature
2.2. Search Technique
2.3. Data Extraction and Literature Screening
2.4. Literature Quality Assessment
2.5. Synthesis of Data and Statistical Evaluation
3. Outcomes
3.1. Outcomes of Literature Study
3.2. Baseline Attributes and Evaluation of the Listed Studies’ Quality
3.3. Meta-Analysis Outcomes
3.3.1. Weight
3.3.2. BMI
3.3.3. Fasting Blood Glucose
3.3.4. Fasting Insulin
3.3.5. HOMA-IR
3.3.6. HbA1c
3.4. Analysis of Subgroups
3.5. Sensitivity Evaluation
3.6. Publication Bias
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author | Year | Study Design | Country | Sample Size | Sex (Male/Female) | Age | BMI | Weight (kg) | Fasting Blood Glucose (mmol/L) | MINORS Score |
---|---|---|---|---|---|---|---|---|---|---|
Jessica [15] | 2020 | Single-arm | USA | 11 | 10/1 | 44.5 ± 14.4 | 41.1 ± 5.0 | / | 5.19 ± 0.8 | 16 |
Xue [16] | 2022 | Single-arm | China | 47 | 25/22 | 57.3 ± 13.4 | 27.7 ± 4.5 | / | 5.3 ± 1.2 | 16 |
Ding [17] | 2022 | Single-arm | China | 11 | 4/7 | 55.7 ± 3.8 | 25.0 ± 0.9 | 70.3 ± 3.6 | 8.5 ± 0.4 | 17 |
Rinott [18] | 2020 | Single-arm | USA | 44 | 42/2 | 53.1 ± 10.0 | 30.9 ± 3.5 | 93.7 ± 14.1 | 5.7 ± 1.1 | 18 |
Yu [19] | 2020 | Single-arm | USA | 12 | 8/4 | 42.5 ± 8.4 | 38.8 ± 6.7 | 110.0 ± 26.0 | 4.8 ± 0.4 | 17 |
Su [20] | 2022 | Single-arm | China | 5 | 3/2 | 57.0 ± 13.2 | 25.2 ± 5.0 | / | 7.1 ± 1.3 | 17 |
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Hu, D.; Zhao, J.; Zhang, H.; Wang, G.; Gu, Z. Fecal Microbiota Transplantation for Weight and Glycemic Control of Obesity as Well as the Associated Metabolic Diseases: Meta-Analysis and Comprehensive Assessment. Life 2023, 13, 1488. https://doi.org/10.3390/life13071488
Hu D, Zhao J, Zhang H, Wang G, Gu Z. Fecal Microbiota Transplantation for Weight and Glycemic Control of Obesity as Well as the Associated Metabolic Diseases: Meta-Analysis and Comprehensive Assessment. Life. 2023; 13(7):1488. https://doi.org/10.3390/life13071488
Chicago/Turabian StyleHu, Diangeng, Jianxin Zhao, Hao Zhang, Gang Wang, and Zhennan Gu. 2023. "Fecal Microbiota Transplantation for Weight and Glycemic Control of Obesity as Well as the Associated Metabolic Diseases: Meta-Analysis and Comprehensive Assessment" Life 13, no. 7: 1488. https://doi.org/10.3390/life13071488