Laryngotracheal Complications after Intubation for COVID-19: A Multicenter Study
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Hospital Name | Community | Number of Cases |
---|---|---|
Hospital Universitario de Fuenlabrada | Community of Madrid | 19 |
Hospital Universitario de Torrejón | Community of Madrid | 7 |
Hospital de Sagunto | Community of Valencia | 5 |
Hospital Universitario Parc Taulí Sabadell | Community of Catalonia | 5 |
Hospital General de Valencia | Community of Valencia | 4 |
Hospital Universitario Son Llàtzer | Community of Balearics Islands | 3 |
Hospital Universitario Severo Ochoa | Community of Madrid | 2 |
Hospital Universitario Galdakao Usansolo | Basque Country | 2 |
Hospital Universitario Fundación Jimenez Diaz | Community of Madrid | 2 |
Demographics Characteristics | |
Gender (% male) | 57.7% |
Age (mean, range), years | 60.6 (33–80) |
Comorbidities | |
None | 8 (16.3%) |
Obesity | 23 (46.9%) |
Arterial hypertension | 21 (42.9%) |
Dyslipidaemia | 16 (32.7%) |
Diabetes mellitus | 14 (28.6%) |
Respiratory insufficiency | 8 (16.3%) |
Hypothyroidism | 4 (8.2%) |
Tobacco use | 13 (26.5%) |
General Symptoms Prior to Intubation | |
Dyspnea | 34 (69.4%) |
Fever | 34 (69.4%) |
Cough | 33 (67.3%) |
Asthenia | 25 (51%) |
Myalgia | 20 (40.1%) |
Headache | 13 (26.5%) |
Arthralgia | 10 (20.4%) |
Diarrhea | 8 (16.3%) |
Nausea/vomiting | 5 (10.2%) |
Post-intubation ENT symptoms | |
Dysphonia | 42 (87.8%) |
Dysphagia | 21 (42.9%) |
Dyspnea | 17 (34.7%) |
Cough | 8 (16.3%) |
Throat clearing | 10 (20.4%) |
Stridor | 5 (10.2%) |
Type of Intubation: | |
Orotracheal | 48 (97.9%) |
Nasotracheal | 1 (2.2%) |
Intubations attempts (mean, range) | 1.3 (1–4) |
Pronation: | |
Number of patients | 36 (73.5%) |
Mean (range), days | 5.3 (1–30) |
Tracheostomy: | |
Number of patients | 22 (44.9%) |
Mean of days of ETI previous tracheostomy | 16.42 (7–31) |
Mean number of ETI days of extubation (range), days | 17.63 (4–77) |
Location of Laryngoscopy Abnormality: | |
Glottis | 44 (89.8%) |
Subglottis | 9 (18.4%) |
Posterior glottis | 53 (10.2%) |
Arytenoids | 3 (6.1%) |
Tracheal | 1 (2%) |
Supraglottis | 1 (2%) |
Type of laryngeal lesion: | |
Altered laryngeal mobility | 39 (79.6%) |
Subglottic stenoses | 6 (12.2%) |
Granulomas | 6 (12.2%) |
Atrophies | 3 (6.1%) |
Synechiae | 2 (4%) |
Tracheocutaneous fistula | 1 (2%) |
Glottic edema | 1 (2%) |
AUTHOR | YEAR | NUMBER OF PATIENTS | SUBSITE | RELEVANT FINDINGS |
---|---|---|---|---|
Gervasio et al. [25] | 2020 | 2 | Subglottic | Stenoses |
Naunheim et al. [10] | 2020 | 20 | Larynx | 40% paralysis, 15% glottic stenoses, and 15% subglottic stenoses |
Thong et al. [26] | 2020 | 1 | Glottic | Bilateral fixation of the cricoarytenoid joints and a granuloma |
Fiacchini et al. [28] | 2021 | 30 | Larynx | 33% tracheal lesions and 17% tracheoesophagic fistula |
Leis-Cofiño et al. [12] | 2021 | 79 | Larynx | 64% paralysis, 29% atrophy, and 7% granuloma |
Neevel et al. [44] | 2021 | 24 | Larynx | Vocal fold motion impairment (50%), early glottic injury (39%), subglottic/tracheal stenosis (22%), and posterior glottic stenosis (17%) |
Rouhani et al. [9] | 2021 | 41 | Alterations GRABS 54% | |
Sandu et al. [18] | 2021 | 4 | Subglottic | Stenoses |
Scholfield et al. [11] | 2021 | 3 | Subglottic/ tracheal | Stenoses |
Watson et al. [13] | 2021 | 18 | Larynx | Multiple injuries |
Aibara et al. [41] | 2022 | 40 | Larynx | 30% vocal fold immobility and 30% laryngeal granuloma |
Allisan-Arrighi et al. [43] | 2022 | 81 | Glottic | Granulomas, arytenoid ankylosis, posterior/subglottic stenosis, and paralysis |
Félix et al. [29] | 2022 | 95 | Larynx- tracheal | Stenoses and paralysis |
Fiacchini et al. [38] | 2022 | 16 | Larynx | Glottic lesions and subglottic stenoses |
Lechien et al. [2] | 2022 | 188 | Larynx | Dysphonia (with or without ETI) |
Piazza et al. [24] | 2022 | 14 | Subglottic | Stenoses |
Rapoport et al. [30] | 2022 | 16 | Larynx | No ETI, and paralysis |
Sakihama et al. [42] | 2022 | 6 | Larynx | Posterior glottic synechiae/stenosis or subglottic/posterior glottic granulomas |
Stratakos et al. [27] | 2022 | 23 | Larynx | Stenoses and tracheoesophageal fistulae |
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Hernández-García, E.; Hernández-Sandemetrio, R.; Quintana-Sanjuás, A.; Zapater-Latorre, E.; González-Herranz, R.; Sanz, L.; Reboll, R.; Pallarés-Martí, B.; Ollé-Moliner, M.; Martínez-Pascual, P.; et al. Laryngotracheal Complications after Intubation for COVID-19: A Multicenter Study. Life 2023, 13, 1207. https://doi.org/10.3390/life13051207
Hernández-García E, Hernández-Sandemetrio R, Quintana-Sanjuás A, Zapater-Latorre E, González-Herranz R, Sanz L, Reboll R, Pallarés-Martí B, Ollé-Moliner M, Martínez-Pascual P, et al. Laryngotracheal Complications after Intubation for COVID-19: A Multicenter Study. Life. 2023; 13(5):1207. https://doi.org/10.3390/life13051207
Chicago/Turabian StyleHernández-García, Estefanía, Rosa Hernández-Sandemetrio, Ana Quintana-Sanjuás, Enrique Zapater-Latorre, Ramón González-Herranz, Lorena Sanz, Rosa Reboll, Beatriz Pallarés-Martí, Montserrat Ollé-Moliner, Paula Martínez-Pascual, and et al. 2023. "Laryngotracheal Complications after Intubation for COVID-19: A Multicenter Study" Life 13, no. 5: 1207. https://doi.org/10.3390/life13051207
APA StyleHernández-García, E., Hernández-Sandemetrio, R., Quintana-Sanjuás, A., Zapater-Latorre, E., González-Herranz, R., Sanz, L., Reboll, R., Pallarés-Martí, B., Ollé-Moliner, M., Martínez-Pascual, P., Gotxi, I., Chacón-Uribe, A., & Plaza, G. (2023). Laryngotracheal Complications after Intubation for COVID-19: A Multicenter Study. Life, 13(5), 1207. https://doi.org/10.3390/life13051207