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Review

P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic Applications in Laboratory and Domestic Animals

1
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
2
Federal Center of Neurosurgery, 625032 Tyumen, Russia
3
Sechenov First Moscow State Medical University, 119991 Moscow, Russia
4
CureLab Oncology Inc., Dedham, MA 02026, USA
5
Department of Molecular Biology, Ariel University, Ariel 40700, Israel
6
Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Einar Ringø
Life 2022, 12(4), 539; https://doi.org/10.3390/life12040539
Received: 22 February 2022 / Revised: 25 March 2022 / Accepted: 31 March 2022 / Published: 6 April 2022
(This article belongs to the Special Issue Feature Papers in Animal Science)
Inflammation is the preceding condition for the development of mild and severe pathological conditions, including various forms of osteopenia, cancer, metabolic syndromes, neurological disorders, atherosclerosis, cardiovascular, lung diseases, etc., in human and animals. The inflammatory status is induced by multifarious intracellular signaling cascades, where cytokines, chemokines, arachidonic acid metabolites, adhesion molecules, immune cells and other components foster a “slow burn” at a local or systemic level. Assuming that countering inflammation limits the development of inflammation-based diseases, a series of new side-effects-free therapies was assessed in experimental and domestic animals. Within the targets of the drug candidates for quenching inflammation, an archetypal autophagic gear, the p62/sqstm1 protein, has currently earned attention from researchers. Intracellular p62 has been recently coined as a multi-task tool associated with autophagy, bone remodeling, bone marrow integrity, cancer progression, and the maintenance of systemic homeostasis. Accordingly, p62 can act as an effective suppressor of inflamm-aging, reducing oxidative stress and proinflammatory signals. Such an operational schedule renders this protein an effective watchdog for degenerative diseases and cancer development in laboratory and pet animals. This review summarizes the current findings concerning p62 activities as a molecular hub for cell and tissues metabolism and in a variety of inflammatory diseases and other pathological conditions. It also specifically addresses the applications of exogenous p62 (DNA plasmid) as an anti-inflammatory and homeostatic regulator in the treatment of osteoporosis, metabolic syndrome, age-related macular degeneration and cancer in animals, and the possible application of p62 plasmid in other inflammation-associated diseases. View Full-Text
Keywords: p62/SQSTM1; inflammation; aging; inflammatory diseases; degenerative diseases p62/SQSTM1; inflammation; aging; inflammatory diseases; degenerative diseases
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MDPI and ACS Style

Sabbieti, M.G.; Marchegiani, A.; Sufianov, A.A.; Gabai, V.L.; Shneider, A.; Agas, D. P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic Applications in Laboratory and Domestic Animals. Life 2022, 12, 539. https://doi.org/10.3390/life12040539

AMA Style

Sabbieti MG, Marchegiani A, Sufianov AA, Gabai VL, Shneider A, Agas D. P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic Applications in Laboratory and Domestic Animals. Life. 2022; 12(4):539. https://doi.org/10.3390/life12040539

Chicago/Turabian Style

Sabbieti, Maria Giovanna, Andrea Marchegiani, Albert A. Sufianov, Vladimir L. Gabai, Alexander Shneider, and Dimitrios Agas. 2022. "P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic Applications in Laboratory and Domestic Animals" Life 12, no. 4: 539. https://doi.org/10.3390/life12040539

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