Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut: Characteristics and Association with Health
Abstract
:1. Introduction
2. The New Class Melainabacteria of the Phylum Cyanobacteria
3. Ecology of Melainabacteria
4. The Health Relevance of Melainabacteria in the Human Gut
4.1. Neurodevelopment and Neurodegeneration
4.2. Gastrointestinal and Metabolic Diseases
4.3. Other Diseases
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Strain | Environment | Genome Size (Mbp) | Completeness | GC (%) | Anaerobic | Flagella | Shape | Reference |
---|---|---|---|---|---|---|---|---|
Order Gastranaerophilales | ||||||||
ACD20 | aquifer | 3.0 | Near Complete | 33.5 | anaerobic | + | N.A. | [5] |
MEL.A1 | human gut | 1.9 | Complete | 32.9 | anaerobic | − | N.A. | [5] |
MEL.A2 | human gut | 1.2 | Partial | 30.6 | anaerobic | − | N.A. | [5] |
MEL.B1 | human gut | 2.3 | Complete | 35.3 | anaerobic | + | N.A. | [5] |
MEL.B2 | human gut | 2.3 | Complete | 36.3 | anaerobic | + | N.A. | [5] |
MEL.C1 | human gut | 2.1 | Complete | 34.1 | anaerobic | − | N.A. | [5] |
MEL.C2 | human gut | 2.2 | Near Complete | 35.3 | anaerobic | − | N.A. | [5] |
MEL.C3 | human gut | 1.3 | Partial | 29.9 | anaerobic | − | N.A. | [5] |
Tpq-Mel-01 | termite gut | 0.96 | Partial | 42.5 | anaerobic | + | Rod | [6] |
Zag_221 | koala gut | 1.8 | complete | 38.5 | anaerobic | − | N.A. | [7] |
Zag_1 | koala gut | 2 a | Near Complete | 34.9 | anaerobic | − | N.A. | [7] |
Zag_111 | koala gut | 2.2 a | Near Complete | 36.7 | anaerobic | − | N.A. | [7] |
MH_37 | human gut | 2.2 | complete | 34.1 | anaerobic | − | N.A. | [7] |
Order Caenarcaniphilales | ||||||||
UASB_169 | bioreactor | 1.8 | complete | 27.5 | anaerobic | − | N.A. | [7] |
Order Obscuribacterales | ||||||||
EBPR_351 | bioreactor | 5.5 | near complete | 49.4 | microaerophilic | − | N.A. | [7] |
Order Vampirovibrionales | ||||||||
NCIB 11383 | coculture with Chlorella vulgaris | 3.0 | complete | 51.4 | microaerophilic | + | N.A. | [20] |
AZ_1 | algal cultivation ponds | 2.8 | near complete | 54.8 | microaerophilic | + | Sphere | [21,22] |
AZ_2 | algal cultivation ponds | 3.0 | near complete | 53.0 | microaerophilic | + | Sphere | [21,22] |
Country | Year | Subject | Disease | Gut Cyanobacterial Abundance | Remark | Reference |
---|---|---|---|---|---|---|
Italy | 2020 | Control group (n = 50) vs. diseased group (n = 50) | Amyotrophic lateral sclerosis | Disease group > control group | The finding indicated that cyanobacteria could be involved in the pathogenesis of neurodegenerative diseases | [31] |
China | 2021 | 3-year old healthy children (n = 38) | Neurodevelopment disorder | Gut cyanobacteria negatively correlated with the neurodevelopment in Adaptation | The finding implied the negative effect of cyanobacteria on neurodevelopment in adaptation | [32] |
China | 2016 | Control group (n = 20) vs. diseased group (n = 31) | Colon adenomas | Disease group > control | The finding implied the association between the colorectal pre-neoplastic lesion and the increase in gut cyanobacterial abundance. | [33] |
China | 2021 | Healthy infants (n = 25), infants with acute rotaviral gastroenteritis (n = 18), infants with acute noraviral gastroenteritis (n = 24) | Acute gastroenteritis | Disease group > control | The finding implied the association between human norovirus infection and the increase in gut cyanobacteria. | [34] |
India | 2017 | Control group (n = 18) vs. diseased group (n = 35) | Cirrhosis | Disease group < control | The finding implied the association between cirrhosis and the reduction in gut cyanobacteria. | [35] |
USA | 2019 | Hispanic/Latino adults (n = 1647) | Obesity | Gut cyanobacteria negatively correlated with obesity | The finding implied the negative association between obesity and gut cyanobacteria. | [36] |
South Africa | 2020 | Rural community (n = 119) vs. urban community (n = 51) | - | Rural community > urban community | Gut Melainabacteria can be more abundant in the rural populations | [37] |
USA | 2020 | Frutcan-sensitive (n = 17) vs. frutcan-tolerant children (n = 21) with irritable bowel syndrome | Irritable bowel syndrome | Fructan-sensitive > fructan-tolerant | Fructan-sensitive children were enriched in the gut cyanobacteria during fructan challenge. | [38] |
China | 2020 | Control group (n = 16) vs. diseased group (n = 14) | Wilson’s Disease | Disease > Control | The finding implied the association between the Wilson’s disease and the higher gut cyanobacterial abundance. | [39] |
China | 2020 | Control group (n = 31) vs. allergy-rhinitis (AR) group (n = 33) | Allergy Rhinitis | Disease > Control | The finding implied the association between allergy rhinitis and the higher gut cyanobacterial abundance. | [40] |
China | 2018 | Healthy controls (n = 41) vs. Lung cancer (n = 41) | Lung cancer | Disease group > Control | The lung cancer group had a significantly higher level of gut cyanobacteria compared to the health group. | [41] |
USA | 2020 | Smokers (n = 36) | - | Gut cyanobacteria positively correlated with exhaled CO levels | The finding implied the positive association between CO level and gut cyanobacteria among the current smokers. | [42] |
China | 2021 | Patients with Graves’ disease (n = 30), Graves’ orbitopathy (n = 33) vs. healthy subjects (n = 32) | Graves’ disease Graves’ orbitopathy | Significant difference in the gut cyanobacterial abundance among the studied groups. | The finding implied the association of the changing gut cyanobacterial abundance with Graves’ disease and Graves’ orbitopathy. | [43] |
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Hu, C.; Rzymski, P. Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut: Characteristics and Association with Health. Life 2022, 12, 476. https://doi.org/10.3390/life12040476
Hu C, Rzymski P. Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut: Characteristics and Association with Health. Life. 2022; 12(4):476. https://doi.org/10.3390/life12040476
Chicago/Turabian StyleHu, Chenlin, and Piotr Rzymski. 2022. "Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut: Characteristics and Association with Health" Life 12, no. 4: 476. https://doi.org/10.3390/life12040476