Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19
Abstract
:1. Introduction
2. The Case
3. Discussion
3.1. Pathophysiology
3.2. Prevalence and Mortality
3.3. Risk Factors
3.4. Symptomatology
3.5. Imaging Studies
3.6. Laboratory Tests
3.7. Treatment
3.8. Prognosis
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lab Finding | Admission | After 6 h | After 12 h |
---|---|---|---|
Platelet count (×109/L) | 39 | 92 | 65 |
Hemoglobin (g/dL) | 14.7 | 15.5 | 16.8 |
WBC (×109/L) | 8.18 | 13.44 | 23.13 |
APTT (s) | 42.1 | 61.6 | 51.2 |
PT (s) | 12.9 | 12.9 | 13.6 |
INR | 1.14 | 1.14 | 1.21 |
D-Dimer (µgFEU/L) | 125,780 | 153,660 | 157,660 |
Fibrinogen (mg/dL) | - | 183 | 314 |
AST | - | 38 | 99 |
ALT | - | 34 | 71 |
Creatinine (mg/dL) | 1.0 | 1.3 | 2.0 |
eGFR (ml/min/1.73 m2) | >90 | >90 | 42 |
Urea (mg/dL) | 33 | 32 | 54 |
CRP (mg/dL) | 2.3 | 5.2 | - |
Type of VITT | Description |
---|---|
Definite VITT | All five of the following criteria:
|
Probable VITT |
|
Possible VITT |
|
Unlikely VITT |
|
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Szypowski, W.; Dębiec, A.; Świstak, J.; Nowocień, M.; Rzepecki, P.; Możański, M.; Staszewski, J.; Stępień, A. Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19. Life 2022, 12, 168. https://doi.org/10.3390/life12020168
Szypowski W, Dębiec A, Świstak J, Nowocień M, Rzepecki P, Możański M, Staszewski J, Stępień A. Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19. Life. 2022; 12(2):168. https://doi.org/10.3390/life12020168
Chicago/Turabian StyleSzypowski, Wojciech, Aleksander Dębiec, Jarosław Świstak, Maciej Nowocień, Piotr Rzepecki, Marcin Możański, Jacek Staszewski, and Adam Stępień. 2022. "Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19" Life 12, no. 2: 168. https://doi.org/10.3390/life12020168
APA StyleSzypowski, W., Dębiec, A., Świstak, J., Nowocień, M., Rzepecki, P., Możański, M., Staszewski, J., & Stępień, A. (2022). Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19. Life, 12(2), 168. https://doi.org/10.3390/life12020168