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Article

Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children

1
Department of Automatics, Biocybernetics and Robotics, Jožef Stefan Institute, 1000 Ljubljana, Slovenia
2
Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia
3
Institute of Sport Sciences, University of Lausanne, 1015 Lausanne, Switzerland
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School of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece
5
Department of Pediatric Neurology, University Children’s Hospital Ljubljana, 1000 Ljubljana, Slovenia
6
be.care SA, 1020 Renens, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Nicola Smania, Nicola Valè and Jean-Paul Richalet
Life 2022, 12(1), 79; https://doi.org/10.3390/life12010079
Received: 9 November 2021 / Revised: 17 December 2021 / Accepted: 5 January 2022 / Published: 6 January 2022
(This article belongs to the Special Issue Cellular and Functional Response to Hypoxia)
Pre-term birth is associated with numerous cardio-respiratory sequelae in children. Whether these impairments impact the responses to exercise in normoxia or hypoxia remains to be established. Fourteen prematurely-born (PREM) (Mean ± SD; gestational age 29 ± 2 weeks; age 9.5 ± 0.3 years), and 15 full-term children (CONT) (gestational age 39 ± 1 weeks; age 9.7 ± 0.9 years), underwent incremental exercise tests to exhaustion in normoxia (FiO2 = 20.9%) and normobaric hypoxia (FiO2 = 13.2%) on a cycle ergometer. Cardio-respiratory variables were measured throughout. Peak power output was higher in normoxia than hypoxia (103 ± 17 vs. 77 ± 18 W; p < 0.001), with no difference between CONT and PREM (94 ± 23 vs. 86 ± 19 W; p = 0.154). VO2peak was higher in normoxia than hypoxia in CONT (50.8 ± 7.2 vs. 43.8 ± 9.9 mL·kg−1·min−1; p < 0.001) but not in PREM (48.1 ± 7.5 vs. 45.0 ± 6.8 mL·kg−1·min−1; p = 0.137; interaction p = 0.044). Higher peak heart rate (187 ± 11 vs. 180 ± 10 bpm; p = 0.005) and lower stroke volume (72 ± 13 vs. 77 ± 14 mL; p = 0.004) were observed in normoxia versus hypoxia in CONT, with no such differences in PREM (p = 0.218 and >0.999, respectively). In conclusion, premature birth does not appear to exacerbate the negative effect of hypoxia on exercise capacity in children. Further research is warranted to identify whether prematurity elicits a protective effect, and to clarify the potential underlying mechanisms. View Full-Text
Keywords: altitude; children; exercise capacity; hypoxia; prematurity altitude; children; exercise capacity; hypoxia; prematurity
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MDPI and ACS Style

Narang, B.J.; Manferdelli, G.; Kepic, K.; Sotiridis, A.; Osredkar, D.; Bourdillon, N.; Millet, G.P.; Debevec, T. Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children. Life 2022, 12, 79. https://doi.org/10.3390/life12010079

AMA Style

Narang BJ, Manferdelli G, Kepic K, Sotiridis A, Osredkar D, Bourdillon N, Millet GP, Debevec T. Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children. Life. 2022; 12(1):79. https://doi.org/10.3390/life12010079

Chicago/Turabian Style

Narang, Benjamin J., Giorgio Manferdelli, Katja Kepic, Alexandros Sotiridis, Damjan Osredkar, Nicolas Bourdillon, Grégoire P. Millet, and Tadej Debevec. 2022. "Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children" Life 12, no. 1: 79. https://doi.org/10.3390/life12010079

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