Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Criteria for Combining the Transcriptome Sequencing Data of from Three Published Psoriatic Datasets
2.2. RNA Sequencing Data Processing
2.3. Differential Expression Analysis
2.4. Functional Annotation, Enrichment Analysis, and Statistics
3. Results
3.1. Peripheral Nervous System-Associated Transcript Expression Alterations in Psoriasis
3.2. Differentially Expressed Transcripts Affecting Axon-Related Alterations in Non-Lesional and Lesional Psoriatic Skin
3.3. Semaphorin-Plexin Signaling, An Important Regulator of Axon Formation, Is Differentially Affected in Non-Lesional and Lesional Psoriatic Skin
3.4. ROBO-DCC-UNC5 Signaling Regulates Axon Formation and Differentially Affected in Non-Lesional and Lesional Psoriatic Skin
3.5. Disturbed WNT5A Signaling Potentially Affect Cutaneous Axon Growth in Psoriasis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Categories | Functions | Comparison | p-Value | Number of Molecules |
---|---|---|---|---|
Nervous System Development and Function | Morphology of nervous system | NL vs. H | 4.11E-17 | 236 |
L vs. H | 5.28E-32 | 637 | ||
Nervous System Development and Function, Neurological Disease | Abnormal morphology of nervous system | NL vs. H | 4.95E-13 | 188 |
L vs. H | 2.80E-20 | 495 | ||
Nervous System Development and Function, Tissue Morphology | Morphology of nervous tissue | NL vs. H | 1.11E-12 | 165 |
L vs. H | 5.25E-22 | 439 | ||
Nervous System Development and Function, Organismal Development, Tissue Development | Morphogenesis of nervous tissue | NL vs. H | 4.70E-10 | 144 |
L vs. H | 4.46E-22 | 405 | ||
Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Nervous System Development and Function, Organismal Development, Tissue Development | Neuritogenesis | NL vs. H | 5.26E-10 | 142 |
L vs. H | 6.62E-22 | 399 | ||
Cell Morphology, Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Organismal Development, Tissue Development | Morphogenesis of neurons | NL vs. H | 6.60E-10 | 143 |
L vs. H | 6.85E-22 | 403 | ||
Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development | Development of neurons | NL vs. H | 1.12E-09 | 177 |
L vs. H | 2.14E-24 | 517 |
GO Term | Description | Comparison | p-Value | FDR q-Value | Enrichment (N, B, n, b) |
---|---|---|---|---|---|
GO:0010975 | Regulation of neuron projection development | NL vs. H | 1.98E-4 | 2.74E-2 | 1.72 (1442, 229, 139, 38) |
L vs. H | 6.66E-10 | 2.79E-7 | 1.64 (1594, 260, 389, 104) | ||
GO:0045664 | Regulation of neuron differentiation | NL vs. H | 2.68E-4 | 3.35E-2 | 1.67 (1442, 249, 139, 40) |
L vs. H | 6.63E-11 | 4.07E-8 | 1.64 (1594, 285, 389, 114) | ||
GO:0071526 | Semaphorin-plexin signaling pathway | NL vs. H | 4.09E-4 | 4.07E-2 | 5.19 (1442, 12, 139, 6) |
L vs. H | 2.3E-5 | 1.37E-3 | 2.96 (1594, 18, 389, 13) |
GO Term | Description | Comparison | p-Value | FDR q-Value | Enrichment (N, B, n, b) |
---|---|---|---|---|---|
GO:0048812 | Neuron projection morphogenesis | L vs. H | 2.94E-10 | 1.43E-7 | 1.96 (1594, 138, 389, 66) |
GO:0097485 | Neuron projection guidance | 8.37E-7 | 9.17E-5 | 1.78 (1594, 124, 389, 54) | |
GO:0031175 | Neuron projection development | 9.31E-7 | 9.74E-5 | 1.68 (1594, 159, 389, 65) | |
GO:0010976 | Positive regulation of neuron projection development | 3.15E-6 | 2.54E-4 | 1.69 (1594, 141, 389, 58) | |
GO:0010977 | Negative regulation of neuron projection development | 9.99E-5 | 4.76E-3 | 1.74 (1594, 87, 389, 37) |
GO Term | Description | Comparison | p-Value | FDR q-Value | Enrichment (N, B, n, b) |
---|---|---|---|---|---|
GO:0050770 | Regulation of axonogenesis | L vs. H | 6.36E-7 | 7.32E-5 | 1.89 (1594, 102, 389, 47) |
GO:0007411 | Axon guidance | 8.37E-7 | 9.06E-5 | 1.78 (1594, 124, 389, 54) | |
GO:1902668 | Negative regulation of axon guidance | 8.36E-5 | 4.2E-3 | 3.00 (1594, 15, 389, 11) | |
GO:0048843 | Negative regulation of axon extension involved in axon guidance | 9.41E-5 | 4.56E-3 | 3.15 (1594, 13, 389, 10) | |
GO:0050771 | Negative regulation of axonogenesis | 2.61E-4 | 1.07E-2 | 2.00 (1594, 45, 389, 22) | |
GO:0008045 | Motor neuron axon guidance | 6.07E-4 | 2.21E-2 | 2.73 (1594, 15, 389, 10) | |
GO:0048841 | Regulation of axon extension involved in axon guidance | 6.07E-4 | 2.2E-2 | 2.73 (1594, 15, 389, 10) | |
GO:1902667 | Regulation of axon guidance | 9.35E-4 | 3.19E-2 | 2.50 (1594, 18, 389, 11) |
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Romhányi, D.; Szabó, K.; Kemény, L.; Sebestyén, E.; Groma, G. Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis. Life 2022, 12, 111. https://doi.org/10.3390/life12010111
Romhányi D, Szabó K, Kemény L, Sebestyén E, Groma G. Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis. Life. 2022; 12(1):111. https://doi.org/10.3390/life12010111
Chicago/Turabian StyleRomhányi, Dóra, Kornélia Szabó, Lajos Kemény, Endre Sebestyén, and Gergely Groma. 2022. "Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis" Life 12, no. 1: 111. https://doi.org/10.3390/life12010111