Next Article in Journal
Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context?
Previous Article in Journal
The Role of Autophagy Modulated by Exercise in Cancer Cachexia
Article

Action of Extracellular Proteases of Aspergillus flavus and Aspergillus ochraceus Micromycetes on Plasma Hemostasis Proteins

1
Biological Faculty, M.V. Lomonosov Moscow State University, 199234 Moscow, Russia
2
All-Russian Scientific Research Veterinary Institute of Pathology, Pharmacology and Therapy, 394087 Voronezh, Russia
3
Institut für Agrar- und Ernährungswissenschaften, Martin-Luther-University Halle-Wittenberg, 06108 Halle, Germany
4
Department of Public Health and Infectious Disease, “La Sapienza” University of Rome, 00185 Rome, Italy
5
International Biotechnological Center, M.V. Lomonosov Moscow State University, 199234 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Lei Wan
Life 2021, 11(8), 782; https://doi.org/10.3390/life11080782
Received: 26 June 2021 / Revised: 26 July 2021 / Accepted: 31 July 2021 / Published: 2 August 2021
(This article belongs to the Section Microbiology)
In this study, we investigated the properties of proteolytic enzymes of two species of Aspergillus, Aspergillus flavus 1 (with a high degree of pathogenicity) and Aspergillus ochraceus L-1 (a conditional pathogen), and their effects on various components of the hemostasis system (in vitro) in the case of their penetration into the bloodstream. We showed that micromycete proteases were highly active in cleaving both globular (albuminolysis) and fibrillar (fibrin) proteins, and, to varying degrees, they could coagulate the plasma of humans and animals (due to proteolysis of factors of the blood coagulation cascade) but were not able to coagulate fibrinogen. The proteases of both Aspergillus fully hydrolyzed thrombi in 120–180 min. Micromycetes did not show hemolytic activity but were able to break down hemoglobin. View Full-Text
Keywords: Aspergillus; extracellular proteases; fibrinolysis; thrombolysis; plasma coagulation Aspergillus; extracellular proteases; fibrinolysis; thrombolysis; plasma coagulation
Show Figures

Figure 1

MDPI and ACS Style

Osmolovskiy, A.A.; Schmidt, L.; Orekhova, A.V.; Komarevtsev, S.K.; Kreyer, V.G.; Shabunin, S.V.; Egorov, N.S. Action of Extracellular Proteases of Aspergillus flavus and Aspergillus ochraceus Micromycetes on Plasma Hemostasis Proteins. Life 2021, 11, 782. https://doi.org/10.3390/life11080782

AMA Style

Osmolovskiy AA, Schmidt L, Orekhova AV, Komarevtsev SK, Kreyer VG, Shabunin SV, Egorov NS. Action of Extracellular Proteases of Aspergillus flavus and Aspergillus ochraceus Micromycetes on Plasma Hemostasis Proteins. Life. 2021; 11(8):782. https://doi.org/10.3390/life11080782

Chicago/Turabian Style

Osmolovskiy, Alexander A., Laura Schmidt, Anastasia V. Orekhova, Sergey K. Komarevtsev, Valeriana G. Kreyer, Sergey V. Shabunin, and Nikolay S. Egorov. 2021. "Action of Extracellular Proteases of Aspergillus flavus and Aspergillus ochraceus Micromycetes on Plasma Hemostasis Proteins" Life 11, no. 8: 782. https://doi.org/10.3390/life11080782

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop