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Irreversible Electroporation for Prostate Cancer

EJ Whitten Foundation Prostate Cancer Research Centre, Epworth HealthCare, Richmond, VIC 3121, Australia
Department of Surgery, University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia
Fakultas Kedokteran, Universitas Indonesia, Jakarta Pusat 10430, Indonesia
Department of Urology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
Author to whom correspondence should be addressed.
Academic Editors: Bethtrice Thompson Elliott and Silvia Caggia
Life 2021, 11(6), 490;
Received: 30 March 2021 / Revised: 6 May 2021 / Accepted: 24 May 2021 / Published: 27 May 2021
(This article belongs to the Special Issue Chemotherapy and Metastasis: New Insights in Genitourinary Cancers)
Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has significant risks of post-treatment side effects. Focal therapy has emerged as a potential form of treatment that can achieve similar oncological outcomes to radical treatment while preserving functional outcomes and decreasing rates of adverse effects. Irreversible electroporation (IRE) is one such form of focal therapy which utilises pulsatile electrical currents to ablate tissue. This modality of treatment is still in an early research phase, with studies showing that IRE is a safe procedure that can offer good short-term oncological outcomes whilst carrying a lower risk of poor functional outcomes. We believe that based on these results, future well-designed clinical trials are warranted to truly assess its efficacy in treating men with localised prostate cancer. View Full-Text
Keywords: prostate cancer; irreversible electroporation; focal therapy; surgery prostate cancer; irreversible electroporation; focal therapy; surgery
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MDPI and ACS Style

Ong, S.; Leonardo, M.; Chengodu, T.; Bagguley, D.; Lawrentschuk, N. Irreversible Electroporation for Prostate Cancer. Life 2021, 11, 490.

AMA Style

Ong S, Leonardo M, Chengodu T, Bagguley D, Lawrentschuk N. Irreversible Electroporation for Prostate Cancer. Life. 2021; 11(6):490.

Chicago/Turabian Style

Ong, Sean, Matthew Leonardo, Thilakavathi Chengodu, Dominic Bagguley, and Nathan Lawrentschuk. 2021. "Irreversible Electroporation for Prostate Cancer" Life 11, no. 6: 490.

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