Butyrate: A Link between Early Life Nutrition and Gut Microbiome in the Development of Food Allergy
Abstract
1. Introduction
2. Gut Dysbiosis in Food Allergy
2.1. Evidence from Human Observational Studies
2.2. Evidence from Animal Models of Food Allergy
3. Interrelation among Nutrition, Gut Microbiome, and Immune System: The Role of Butyrate
3.1. Fibers and SCFA Butyrate Production by Gut Microbiome
3.2. Reduced Fecal Levels of SCFA Butyrate in Food Allergy: Evidence from Human Observational Studies
3.3. Early Life Nutrition and SCFA Butyrate in Food Allergy
3.3.1. Breastfeeding: Butyrate as Bioactive Human Milk Protective Component against Food Allergy
3.3.2. Food Allergy and Relation to Diet and Microbial Metabolites
3.3.3. Emerging Role of Butyrate in the Active Diet-Therapy in Pediatric Patients with Cow’s Milk Allergy
3.4. Butyrate: Immune and Non-Immune Mechanisms of Action Against Food Allergy
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
ALDH | Aldehyde dehydrogenases |
eHCF | Extensively hydrolyzed casein formula |
FoxP3 | Forkhead box P3 |
GPCRs | G-protein coupled receptors |
HDAC | Histone deacetylases |
IECs | Intestinal epithelial cells |
ILC | Innate lymphoid cells |
IFNγ | Interferon gamma |
IL | Interleukin |
LGG | Lactobacillus rhamnosus GG |
MUC2 | Mucin2 |
NLRP3 | NOD-, LRR-, and pyrin domain-containing protein 3 |
PBMCs | Peripheral blood mononuclear cells |
RALDH | Retinaldehyde dehydrogenases |
RORγt | Retinoic acid-related orphan receptor γt |
SCFAs | Short-chain fatty acids |
Th | T helper |
Tregs | Regulatory T cells |
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Cait et al. 2019 (n = 105) | ↓ Fecal levels of SCFA butyrate (stool samples collected at 3 months and 1 year of age) | ↑ Food allergy/food sensitization at 1 and 3 years | Ref. [10] |
Roduit et al. 2018 (n = 301) | ↑ Fecal levels of SCFA butyrate (stool samples collected at 1 year of age) | ↓ Food allergy/food sensitization up to 6 years | Ref. [44] |
Sandin et al. 2009 (n = 139) | ↓ Fecal levels of SCFA butyrate (stool samples collected at 1 and 4 year of age) | ↑ Food allergy/food sensitization at 1 and 4 years | Ref. [43] |
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Di Costanzo, M.; De Paulis, N.; Biasucci, G. Butyrate: A Link between Early Life Nutrition and Gut Microbiome in the Development of Food Allergy. Life 2021, 11, 384. https://doi.org/10.3390/life11050384
Di Costanzo M, De Paulis N, Biasucci G. Butyrate: A Link between Early Life Nutrition and Gut Microbiome in the Development of Food Allergy. Life. 2021; 11(5):384. https://doi.org/10.3390/life11050384
Chicago/Turabian StyleDi Costanzo, Margherita, Nicoletta De Paulis, and Giacomo Biasucci. 2021. "Butyrate: A Link between Early Life Nutrition and Gut Microbiome in the Development of Food Allergy" Life 11, no. 5: 384. https://doi.org/10.3390/life11050384
APA StyleDi Costanzo, M., De Paulis, N., & Biasucci, G. (2021). Butyrate: A Link between Early Life Nutrition and Gut Microbiome in the Development of Food Allergy. Life, 11(5), 384. https://doi.org/10.3390/life11050384