Lung Microbiome in Cystic Fibrosis
1
Dipartimento di Scienze Mediche Traslazionali, University of Campania “L. Vanvitelli”, 80131 Napoli, Italy
2
CEINGE, Biotecnologie Avanzate, 80145 Napoli, Italy
3
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80145 Napoli, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Anna Szóstek-Mioduchowska, Graça Ferreira-Dias, Beenu Moza Jalali and Beenu Moza Jalali
Life 2021, 11(2), 94; https://doi.org/10.3390/life11020094
Received: 28 December 2020
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Revised: 21 January 2021
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Accepted: 22 January 2021
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Published: 27 January 2021
(This article belongs to the Special Issue Current Concepts in Tissue Fibrosis—Common and Distinct Pathways)
The defective mucociliary clearance due to CFTR malfunctioning causes predisposition to the colonization of pathogens responsible for the recurrent inflammation and rapid deterioration of lung function in patients with cystic fibrosis (CF). This has also a profound effect on the lung microbiome composition, causing a progressive reduction in its diversity, which has become a common characteristic of patients affected by CF. Although we know that the lung microbiome plays an essential role in maintaining lung physiology, our comprehension of how the microbial components interact with each other and the lung, as well as how these interactions change during the disease’s course, is still at an early stage. Many challenges exist and many questions still to be answered, but there is no doubt that manipulation of the lung microbiome could help to develop better therapies for people affected by CF.
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Keywords:
cystic fibrosis; lung; microbiome; CFTR
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MDPI and ACS Style
Scialo, F.; Amato, F.; Cernera, G.; Gelzo, M.; Zarrilli, F.; Comegna, M.; Pastore, L.; Bianco, A.; Castaldo, G. Lung Microbiome in Cystic Fibrosis. Life 2021, 11, 94. https://doi.org/10.3390/life11020094
AMA Style
Scialo F, Amato F, Cernera G, Gelzo M, Zarrilli F, Comegna M, Pastore L, Bianco A, Castaldo G. Lung Microbiome in Cystic Fibrosis. Life. 2021; 11(2):94. https://doi.org/10.3390/life11020094
Chicago/Turabian StyleScialo, Filippo, Felice Amato, Gustavo Cernera, Monica Gelzo, Federica Zarrilli, Marika Comegna, Lucio Pastore, Andrea Bianco, and Giuseppe Castaldo. 2021. "Lung Microbiome in Cystic Fibrosis" Life 11, no. 2: 94. https://doi.org/10.3390/life11020094
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