Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila
Abstract
:1. Introduction
2. Materials and Methods
2.1. Model and Data
2.2. Model Fitting and Hypotheses
2.3. Parameter Optimization
3. Results
3.1. Position-Specific Models for Hunchback Expression in Wild Type Embryos
3.2. Modeling Gt Protein Dynamics in Wild-Type Embryos and Kruppel Mutants
3.3. Model Fails to Reproduce Full Dynamics of Even-Skipped Expression
4. Discussion
4.1. Model Predicts Position-Specific Regulation of Hb Protein Production
4.2. Genotype-Specific Modeling of Gt Protein Dynamics
4.3. Dynamic Sculpting of Eve Pattern: Modeling Failures and Perspectives
4.4. Limitations of the Modeling Approach
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
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Duk, M.A.; Gursky, V.V.; Samsonova, M.G.; Surkova, S.Y. Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila. Life 2021, 11, 1232. https://doi.org/10.3390/life11111232
Duk MA, Gursky VV, Samsonova MG, Surkova SY. Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila. Life. 2021; 11(11):1232. https://doi.org/10.3390/life11111232
Chicago/Turabian StyleDuk, Maria A., Vitaly V. Gursky, Maria G. Samsonova, and Svetlana Yu. Surkova. 2021. "Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila" Life 11, no. 11: 1232. https://doi.org/10.3390/life11111232