Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals

Kishimoto, Kazuya; Nozaki, Yuji; Sakurai, Toshiharu; Kinoshita, Koji; Funauchi, Masanori; Matsumura, Itaru

doi:10.3390/life11101019

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Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals

by

Kazuya Kishimoto

¹,

Yuji Nozaki

^1,*

,

Toshiharu Sakurai

²,

Koji Kinoshita

¹,

Masanori Funauchi

¹ and

Itaru Matsumura

¹

Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osaka-Sayama, Osaka 589-8511, Japan

²

Department of Gastroenterology and Hepatology, Faculty of Medicine, Kindai University, Osaka-Sayama, Osaka 589-8511, Japan

^*

Author to whom correspondence should be addressed.

Life 2021, 11(10), 1019; https://doi.org/10.3390/life11101019

Submission received: 24 August 2021 / Revised: 10 September 2021 / Accepted: 24 September 2021 / Published: 28 September 2021

(This article belongs to the Special Issue New Insights in Autoimmune Arthritis and Nephritis)

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Abstract

We report a 14-year-old man with Crohn’s disease (CD) who developed right upper arm pain while being treated with the anti-tumor necrosis factor (TNF)-alpha monoclonal antibody, infliximab. There were no symptoms suggestive of active CD, but the inflammatory response was high, and a contrast-enhanced CT showed the occlusion of the right brachial artery. We diagnosed the patient as having Takayasu’s arteritis (TA) and started treatment with corticosteroids, then tapered off the steroids as the symptoms of TA resolved. Later, TA flared up, and his treatment was changed from infliximab to an anti-IL-6 receptor antibody, tocilizumab. The change to TCZ stabilized TA, but exacerbated CD. It is difficult to control both diseases at the same time, and the choice of biologics for treatment must be carefully considered.

Keywords: Crohn’s disease; Takayasu’s arteritis; anti-TNFα monoclonal antibody; anti-IL-6 receptor antibody

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MDPI and ACS Style

Kishimoto, K.; Nozaki, Y.; Sakurai, T.; Kinoshita, K.; Funauchi, M.; Matsumura, I. Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals. Life 2021, 11, 1019. https://doi.org/10.3390/life11101019

AMA Style

Kishimoto K, Nozaki Y, Sakurai T, Kinoshita K, Funauchi M, Matsumura I. Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals. Life. 2021; 11(10):1019. https://doi.org/10.3390/life11101019

Chicago/Turabian Style

Kishimoto, Kazuya, Yuji Nozaki, Toshiharu Sakurai, Koji Kinoshita, Masanori Funauchi, and Itaru Matsumura. 2021. "Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals" Life 11, no. 10: 1019. https://doi.org/10.3390/life11101019

APA Style

Kishimoto, K., Nozaki, Y., Sakurai, T., Kinoshita, K., Funauchi, M., & Matsumura, I. (2021). Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals. Life, 11(10), 1019. https://doi.org/10.3390/life11101019

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Takayasu’s Arteritis Diagnosed in an Adolescent Patient with Crohn’s Disease: Management of Biologicals

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