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Review

Radiation-Induced Cerebro-Ophthalmic Effects in Humans

1
National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine
2
Dipartimento di Medicina Clinica e Sperimentale Section of Psychiatry, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy
3
Dipartimento di Biochimica Biologia Molecolare, University of Siena, 53100 Siena, Italy
4
Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine, 9 Vernadsky Street, 49044 Dnipro, Ukraine
*
Author to whom correspondence should be addressed.
Life 2020, 10(4), 41; https://doi.org/10.3390/life10040041
Received: 28 March 2020 / Revised: 8 April 2020 / Accepted: 12 April 2020 / Published: 16 April 2020
(This article belongs to the Section Radiobiology, Nuclear Medicine and Medical Imaging)
Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both cognitive and visual impairments. The aim of this paper was to review and analyze the current literature, and to comment on the ensuing findings in the light of our personal contributions in this field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus, Embase, PsycINFO and Google Scholar English papers published from January 2000 to January 2020. The results showed that prenatally or childhood-exposed individuals are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood and medical/interventional radiologists, the most frequent IR-induced ophthalmic effects include cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with specific neurocognitive deficits. According to available information that eye alterations may induce or may be associated with brain dysfunctions and vice versa, we propose to label this relationship “eye-brain axis”, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable markers of possible low dose IR-induced brain damage. View Full-Text
Keywords: ionizing radiation; brain; neurocognitive deficits; glaucoma; optic neuropathy; retinopathy; angiopathy ionizing radiation; brain; neurocognitive deficits; glaucoma; optic neuropathy; retinopathy; angiopathy
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MDPI and ACS Style

Loganovsky, K.N.; Marazziti, D.; Fedirko, P.A.; Kuts, K.V.; Antypchuk, K.Y.; Perchuk, I.V.; Babenko, T.F.; Loganovska, T.K.; Kolosynska, O.O.; Kreinis, G.Y.; Gresko, M.V.; Masiuk, S.V.; Mucci, F.; Zdorenko, L.L.; Della Vecchia, A.; Zdanevich, N.A.; Garkava, N.A.; Dorichevska, R.Y.; Vasilenko, Z.L.; Kravchenko, V.I.; Drosdova, N.V. Radiation-Induced Cerebro-Ophthalmic Effects in Humans. Life 2020, 10, 41. https://doi.org/10.3390/life10040041

AMA Style

Loganovsky KN, Marazziti D, Fedirko PA, Kuts KV, Antypchuk KY, Perchuk IV, Babenko TF, Loganovska TK, Kolosynska OO, Kreinis GY, Gresko MV, Masiuk SV, Mucci F, Zdorenko LL, Della Vecchia A, Zdanevich NA, Garkava NA, Dorichevska RY, Vasilenko ZL, Kravchenko VI, Drosdova NV. Radiation-Induced Cerebro-Ophthalmic Effects in Humans. Life. 2020; 10(4):41. https://doi.org/10.3390/life10040041

Chicago/Turabian Style

Loganovsky, Konstantin N., Donatella Marazziti, Pavlo A. Fedirko, Kostiantyn V. Kuts, Katerina Y. Antypchuk, Iryna V. Perchuk, Tetyana F. Babenko, Tetyana K. Loganovska, Olena O. Kolosynska, George Y. Kreinis, Marina V. Gresko, Sergii V. Masiuk, Federico Mucci, Leonid L. Zdorenko, Alessandra Della Vecchia, Natalia A. Zdanevich, Natalia A. Garkava, Raisa Y. Dorichevska, Zlata L. Vasilenko, Victor I. Kravchenko, and Nataliya V. Drosdova 2020. "Radiation-Induced Cerebro-Ophthalmic Effects in Humans" Life 10, no. 4: 41. https://doi.org/10.3390/life10040041

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