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Article

β-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice

1
Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Akademika Zabolotnogo Street, 03680 Kyiv, Ukraine
2
Laboratory of Molecular Medical Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland
3
Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, 46-580 Warsaw, Poland
4
Department of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4 Bogomoletz Street, 01024 Kyiv, Ukraine
*
Authors to whom correspondence should be addressed.
Life 2020, 10(12), 357; https://doi.org/10.3390/life10120357
Received: 15 November 2020 / Revised: 10 December 2020 / Accepted: 16 December 2020 / Published: 17 December 2020
(This article belongs to the Special Issue Exercise Biomechanics and Physiology)
The role of canonical Wnt signaling in metabolic regulation and development of physiological cardiac hypertrophy remains largely unknown. To explore the function of β-catenin in the regulation of cardiac metabolism and physiological cardiac hypertrophy development, we used mice heterozygous for cardiac-specific β-catenin knockout that were subjected to a swimming training model. β-Catenin haploinsufficient mice subjected to endurance training displayed a decreased β-catenin transcriptional activity, attenuated cardiomyocytes hypertrophic growth, and enhanced activation of AMP-activated protein kinase (AMPK), phosphoinositide-3-kinase–Akt (Pi3K–Akt), and mitogen-activated protein kinase/extracellular signal-regulated kinases 1/2 (MAPK/Erk1/2) signaling pathways compared to trained wild type mice. We further observed an increased level of proteins involved in glucose aerobic metabolism and β-oxidation along with perturbed activity of mitochondrial oxidative phosphorylation complexes (OXPHOS) in trained β-catenin haploinsufficient mice. Taken together, Wnt/β-catenin signaling appears to govern metabolic regulatory programs, sustaining metabolic plasticity in adult hearts during the adaptation to endurance training. View Full-Text
Keywords: Wnt/β-catenin signaling; training-induced heart hypertrophy; glucose metabolism; lipid metabolism; β-oxidation; oxidative phosphorylation Wnt/β-catenin signaling; training-induced heart hypertrophy; glucose metabolism; lipid metabolism; β-oxidation; oxidative phosphorylation
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MDPI and ACS Style

Balatskyi, V.V.; Palchevska, O.L.; Bortnichuk, L.; Gan, A.-M.; Myronova, A.; Macewicz, L.L.; Navrulin, V.O.; Tumanovska, L.V.; Olichwier, A.; Dobrzyn, P.; Piven, O.O. β-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice. Life 2020, 10, 357. https://doi.org/10.3390/life10120357

AMA Style

Balatskyi VV, Palchevska OL, Bortnichuk L, Gan A-M, Myronova A, Macewicz LL, Navrulin VO, Tumanovska LV, Olichwier A, Dobrzyn P, Piven OO. β-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice. Life. 2020; 10(12):357. https://doi.org/10.3390/life10120357

Chicago/Turabian Style

Balatskyi, Volodymyr V., Oksana L. Palchevska, Lina Bortnichuk, Ana-Maria Gan, Anna Myronova, Larysa L. Macewicz, Viktor O. Navrulin, Lesya V. Tumanovska, Adam Olichwier, Pawel Dobrzyn, and Oksana O. Piven 2020. "β-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice" Life 10, no. 12: 357. https://doi.org/10.3390/life10120357

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