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The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

1
Department of Otolaryngology, University of Perugia, 06132 Perugia, Italy
2
Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Life 2020, 10(12), 345; https://doi.org/10.3390/life10120345
Received: 14 November 2020 / Revised: 3 December 2020 / Accepted: 10 December 2020 / Published: 11 December 2020
(This article belongs to the Section Medical Research)
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that ranges from asymptomatic to fatal multi-organ damage. The site of entry and the response of the host to the infection affect the outcomes. The role of the upper airways and the nasal barrier in the prevention of infection is increasingly being recognized. Besides the epithelial lining and the local immune system, the upper airways harbor a community of microorganisms, or microbiota, that takes an active part in mucosal homeostasis and in resistance to infection. However, the role of the upper airway microbiota in COVID-19 is not yet completely understood and likely goes beyond protection from viral entry to include the regulation of the immune response to the infection. Herein, we discuss the hypothesis that restoring endogenous barriers and anti-inflammatory pathways that are defective in COVID-19 patients might represent a valid strategy to reduce infectivity and ameliorate clinical symptomatology. View Full-Text
Keywords: COVID-19; microbiota; upper respiratory tract; tryptophan; aryl hydrocarbon receptor COVID-19; microbiota; upper respiratory tract; tryptophan; aryl hydrocarbon receptor
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MDPI and ACS Style

Di Stadio, A.; Costantini, C.; Renga, G.; Pariano, M.; Ricci, G.; Romani, L. The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19. Life 2020, 10, 345. https://doi.org/10.3390/life10120345

AMA Style

Di Stadio A, Costantini C, Renga G, Pariano M, Ricci G, Romani L. The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19. Life. 2020; 10(12):345. https://doi.org/10.3390/life10120345

Chicago/Turabian Style

Di Stadio, Arianna, Claudio Costantini, Giorgia Renga, Marilena Pariano, Giampietro Ricci, and Luigina Romani. 2020. "The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19" Life 10, no. 12: 345. https://doi.org/10.3390/life10120345

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