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Review

Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections

1
Department of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, St Mary’s Campus, Imperial College London, London W2 1PG, UK
2
Unit for Environmental Sciences and Management, North-West University, Potchefstroom 2520, South Africa
3
Institute of Zoology, Zoological Society of London, London NW1 4RY, UK
4
Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, UK
5
Department of Chemistry, University College London, London WC1H 0AJ, UK
6
UK Centre for Ecology & Hydrology, Wallingford OX10 8BB, UK
*
Author to whom correspondence should be addressed.
Life 2020, 10(12), 315; https://doi.org/10.3390/life10120315
Received: 16 October 2020 / Revised: 15 November 2020 / Accepted: 19 November 2020 / Published: 28 November 2020
(This article belongs to the Special Issue Advances in Fungal -Omics)
Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future. View Full-Text
Keywords: cross-disciplinary; fungal-omics; emerging fungal pathogen cross-disciplinary; fungal-omics; emerging fungal pathogen
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MDPI and ACS Style

Ghosh, P.N.; Brookes, L.M.; Edwards, H.M.; Fisher, M.C.; Jervis, P.; Kappel, D.; Sewell, T.R.; Shelton, J.M.G.; Skelly, E.; Rhodes, J.L. Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections. Life 2020, 10, 315. https://doi.org/10.3390/life10120315

AMA Style

Ghosh PN, Brookes LM, Edwards HM, Fisher MC, Jervis P, Kappel D, Sewell TR, Shelton JMG, Skelly E, Rhodes JL. Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections. Life. 2020; 10(12):315. https://doi.org/10.3390/life10120315

Chicago/Turabian Style

Ghosh, Pria N., Lola M. Brookes, Hannah M. Edwards, Matthew C. Fisher, Phillip Jervis, Dana Kappel, Thomas R. Sewell, Jennifer M.G. Shelton, Emily Skelly, and Johanna L. Rhodes 2020. "Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections" Life 10, no. 12: 315. https://doi.org/10.3390/life10120315

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