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Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
Article

Non-Criteria Antiphospholipid Antibodies: Risk Factors for Endothelial Dysfunction in Women with Pre-Eclampsia

1
Nephrology Service, University Hospital Marqués de Valdecilla, 39008 Santander, Spain
2
Immunology Service, University Hospital Marqués de Valdecilla, 39008 Santander, Spain
3
Obstetrics and Gynecology Service, University Hospital Marqués de Valdecilla, 39008 Santander, Spain
*
Author to whom correspondence should be addressed.
Life 2020, 10(10), 241; https://doi.org/10.3390/life10100241
Received: 14 September 2020 / Revised: 11 October 2020 / Accepted: 12 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Reproductive Health Concerns for Women)
The association between unconventional antiphospholipid antibodies and pre-eclampsia in patients without thrombotic manifestations and its relationship with endothelial dysfunction after delivery has been studied poorly. We included 157 pregnant women, 122 of them having developed pre-eclampsia (56 non-severe and 66 severe). The determination of classical and unconventional, as well as pulse wave velocity and ankle-brachial index were performed at three months after delivery. The prevalence of unconventional antiphospholipid antibodies was 22.9% and 54.9% in patients included in control and pre-eclampsia groups, respectively (p = 0.001). The most frequent antiphospholipid antibody was IgM anti-phosphatidylserine/prothrombin in both cohorts. The presence of IgM anti-phosphatidylserine/prothrombin showed an association with the development of pre-eclampsia (OR = 5.4; CI 95% (2.0–14.9), p = 0.001) with an AUC of 0.744 (p < 0.001). Likewise, IgM anti-phosphatidylserine/prothrombin exhibited a positive linear correlation with pulse wave velocity values (rho = 0.830; p < 0.001) and an association with the presence of pulse wave velocity altered values (OR = 1.33; CI95% (1.10–1.59), p = 0.002). With regard to ankle braquial index values, the presence of IgM anti-phosphatidylserine/prothrombin displayed a weak negative correlation (rho = −0.466; p < 0.001) and an association with altered ankle braquial index values (OR = 1.08; CI 95% (1.04–1.13), p < 0.001). In patients who developed preeclampsia, the presence of IgM anti-phosphatidylserine/prothrombin could be associated with endothelial dysfunction, causing alteration of cardiovascular parameters. View Full-Text
Keywords: pre-eclampsia; antiphospholipid antibodies; antiphosphatidylserine/prothrombin antibodies; pulse wave velocity; ankle-brachial index pre-eclampsia; antiphospholipid antibodies; antiphosphatidylserine/prothrombin antibodies; pulse wave velocity; ankle-brachial index
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MDPI and ACS Style

Belmar Vega, L.; Fernández Fresnedo, G.; Irure Ventura, J.; Orallo Toural, V.; Heras Vicario, M.; Ruiz San Millán, J.C.; Rodrigo, E.; López Hoyos, M. Non-Criteria Antiphospholipid Antibodies: Risk Factors for Endothelial Dysfunction in Women with Pre-Eclampsia. Life 2020, 10, 241. https://doi.org/10.3390/life10100241

AMA Style

Belmar Vega L, Fernández Fresnedo G, Irure Ventura J, Orallo Toural V, Heras Vicario M, Ruiz San Millán JC, Rodrigo E, López Hoyos M. Non-Criteria Antiphospholipid Antibodies: Risk Factors for Endothelial Dysfunction in Women with Pre-Eclampsia. Life. 2020; 10(10):241. https://doi.org/10.3390/life10100241

Chicago/Turabian Style

Belmar Vega, Lara, Gema Fernández Fresnedo, Juan Irure Ventura, Victoria Orallo Toural, Milagros Heras Vicario, Juan C. Ruiz San Millán, Emilio Rodrigo, and Marcos López Hoyos. 2020. "Non-Criteria Antiphospholipid Antibodies: Risk Factors for Endothelial Dysfunction in Women with Pre-Eclampsia" Life 10, no. 10: 241. https://doi.org/10.3390/life10100241

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