The Contractile Phenotype of Skeletal Muscle in TRPV1 Knockout Mice Is Gender-Specific and Exercise-Dependent
Abstract
:1. Introduction
2. Results
2.1. Genotype-Related Differences Were Found in Body Weight and in the Relative Heart, Diaphragm, and Extensor Digitorum Longus Weights, but not in Tibialis Anterior and Soleus Muscles
2.2. Exercise, Female Sex, and TRPV1 Deficiency Improved Muscle Strength
2.3. TRPV1 Deficiency Modified the Contractile Properties of Skeletal Muscles in a Muscle Type-Specific Manner
2.4. Force–Voltage and Force–Frequency Relationships Were Disturbed in Slow-Twitch Muscles but Not in Fast-Twitch Muscles by the TRPV1 Deficiency
2.5. TRPV1 Deficiency Did Not Alter Fatigue Profiles of Fast- and Slow-Twitch Muscles
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Treadmill Protocol
4.3. Grip Test
4.4. Contractile Properties of Fast- and Slow-Twitch Muscles
4.5. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Lafoux, A.; Lotteau, S.; Huchet, C.; Ducreux, S. The Contractile Phenotype of Skeletal Muscle in TRPV1 Knockout Mice Is Gender-Specific and Exercise-Dependent. Life 2020, 10, 233. https://doi.org/10.3390/life10100233
Lafoux A, Lotteau S, Huchet C, Ducreux S. The Contractile Phenotype of Skeletal Muscle in TRPV1 Knockout Mice Is Gender-Specific and Exercise-Dependent. Life. 2020; 10(10):233. https://doi.org/10.3390/life10100233
Chicago/Turabian StyleLafoux, Aude, Sabine Lotteau, Corinne Huchet, and Sylvie Ducreux. 2020. "The Contractile Phenotype of Skeletal Muscle in TRPV1 Knockout Mice Is Gender-Specific and Exercise-Dependent" Life 10, no. 10: 233. https://doi.org/10.3390/life10100233