Abstract
The aim of this study is to provide neighborhood structures in bipolar fuzzy supra topological space and to show the applicability of bipolar fuzzy supra topology to the medical diagnosis problem. Firstly, we give some properties related to bipolar fuzzy points and their neighborhood structure in bipolar fuzzy supra topological spaces. Then, we consider another important structure, “quasi-coincident”, in the case of bipolar fuzzy points and bipolar fuzzy sets. Then, we introduce the corresponding neighborhood structure called “Q-neighborhood system” by using the quasi-coincident relations. Furthermore, we also investigate the characterization of bipolar fuzzy supra topological space in terms of quasi-neighborhoods. Finally, we present a new method to solve medical diagnosis problems by using the bipolar fuzzy score function.
1. Introduction
Throughout the history of humanity, mankind has put forward various disciplines to produce solutions to problems. Over time, these disciplines have been divided into sub-disciplines by being handled through different aspects. Mathematics is one of the oldest disciplines that has shared this fate. Mathematics is separated into many sub-disciplines and has been used effectively to find solutions in different disciplines such as engineering, medicine, and the humanities, especially through the classical set theory approach. However, classical set theory is insufficient to produce an effective solution to all problems encountered.
The notion of fuzzy sets was given by Zadeh [] in 1965. The theory of fuzzy sets is a generalization of classical set theory; fuzzy sets grade elements as belonging to a set. A fuzzy set A defined on the universal set U can be denoted as . Here is a function of the form and is called the membership degree of an arbitrary element .
Intuitionistic fuzzy sets [] were defined by adding the degree of non-membership to fuzzy sets. Thus, this concept helps solve broader, real-life problems. The intuitionistic fuzzy set considers membership and non-membership degrees during analysis. For instance, in the fuzzy set, the degree of sweetness is given in the interval [0, 1], while in an intuitionistic fuzzy set, the degree of sweetness () and the degree of non-sweetness () are added to handle more general problems. In intuitionistic fuzzy sets, we have . Suppose that and , we obtain , but . We could not solve this kind of problem in an intuitionistic fuzzy set. Therefore, Pythagorean fuzzy sets [] were defined, which are more general than intuitionistic fuzzy sets because of their ability to model using incoherent data. These sets are characterized by the condition that the sum of the squares of membership and non-membership grades is less than or equal to 1. Thus, the sum of membership and non-membership grades can exceed 1. Table 1 summarizes the advantages of these structures. By continuing the generalizations of fuzzy sets (neutrosophic fuzzy sets [], picture fuzzy sets [], spherical fuzzy sets [], Pythagorean fuzzy sets []), the definition of bipolar fuzzy set was given by Zhang []. Bipolar-valued fuzzy sets are an extension of fuzzy sets with bipolarity.
Table 1.
Some fuzzy models.
W.R. Zhang [,,] extended the idea of a fuzzy set by introducing the concept of a bipolar fuzzy set. Bipolarity refers to the positive and negative facets of a problem. It is suitable for information containing a feature as well as its opposite, such as sourness and sweetness, competition and cooperation, happiness and grief. Although intuitionistic fuzzy sets and bipolar fuzzy sets appear parallel to each other, they are distinct sets. In comparison, we obtain and , which look like similar to each other. However, in bipolar fuzzy sets, the positive membership degree () of a section shows that the section fairly fulfills the subject and the negative membership degree () of a section represents that the section fairly fulfills the implicit counter property. In intuitionistic fuzzy sets, the membership degree represents the extent to which the element u satisfies property A, while the membership degree signifies the degree to which u satisfies the not-property of A. Given that a counter property is distinct from a not-property, bipolar-valued fuzzy sets and intuitionistic fuzzy sets serve as distinct extensions of traditional fuzzy sets. Figure 1 summarizes the relation of them.
Figure 1.
Relation between fuzzy sets, intuitionistic fuzzy sets, and bipolar fuzzy sets.
Recently, bipolar fuzzy sets have been utilized in various fields of research. Lee [,], defined bipolar fuzzy set operations and obtained their basic algebraic properties. Abdullah et al. [] combined the bipolarity, fuzziness, and parameterization and gave the definition of bipolar fuzzy soft sets in 2014. They also gave an application of bipolar fuzzy soft set in decision-making problems. In 2019, Kim et al. [] defined bipolar fuzzy points and studied the topological structures of bipolar fuzzy sets, such as neighborhood, base, continuity, product, and quotient spaces. In recent years, researchers have also studied the algebraic structures of bipolar fuzzy sets [,,,].
Chang [] (1968) defined topological spaces on fuzzy sets and examined basic properties such as open-closed sets, continuity, and compactness. In 1976, Lowen [] gave a new definition of fuzzy topology and guaranteed that the constant functions are continuous in fuzzy topological spaces in this sense. In Chang’s fuzzy topology, open sets are fuzzy, but the topology comprising those open sets is a subset of the family of fuzzy sets. Fuzzification of openness was first defined by Hohle [] and later extended to L-subsets by Shostak []. Pao-Ming and Ying-Ming [,] defined the concept of a neighborhood of fuzzy points. They also brought out the structures of fuzzy quasi-coincident and Q-neighborhood. The fuzzy topology theory, which has been handled in many ways until today, has now reached a certain maturity. Topological structures of some extensions of fuzzy sets also have been studied. For example intuitonistic fuzzy topology [], neutrosophic fuzzy topology [,], picture fuzzy topology [], bipolar fuzzy topology [], etc.
Supra topology [] was defined by dropping a finite intersection condition of topological spaces. It is fundamental with respect to the investigation of classical topological spaces. Since then, many authors have studied supra topology and its extensions such as (intuitionistic) fuzzy supra topology [,,]. In 2022, Hami et al. [] discussed bipolar fuzzy supra topological spaces as a generalization of supra topologies to bipolar fuzzy topologies.
Neighborhood structures play important roles in (supra) topological spaces. As such, we aim to study neighborhood structures and related properties in bipolar fuzzy supra topological spaces. For this, this paper includes the following sections: In Section 2, we list basic definitions and results that are needed in the subsequent sections. In Section 3, we define the concept of neighborhood structure for a bipolar fuzzy point and generate a bipolar fuzzy supra-topology using the system of neighborhoods (see Theorem 11). The characterization of continuous mappings is also provided in this section. In Section 4, we introduce the concept of quasi-coincidence in bipolar fuzzy sets and obtain some of its properties. Subsequently, we study the Q-neighborhood structure of bipolar fuzzy supra-topological space. In the last section, we propose a method for data analysis within a bipolar fuzzy supra-topological environment as a real-life application, and we present numerical examples of the proposed method.
2. Preliminaries
In this section, we give some definitions and several results related to bipolar fuzzy sets.
Definition 1
([]). Let U be a non-empty set. A bipolar fuzzy set A on U is an object having the form where and are mappings. The positive membership degree represents the satisfaction degree of an element u with respect to the property associated with a bipolar-valued fuzzy set A, while the negative membership degree indicates the satisfaction degree of u with an implicit counter property of bipolar-valued fuzzy set A.
If and , it is the situation that u does not satisfy property of A but somewhat satisfies the counter property of A.
If and , it is the situation that u is regarded as having only positive satisfaction of A.
There are cases where the positive membership degree and the negative membership degree are both non-zero when the membership function of the property overlaps that of its counter property over certain elements in U.
The set of all bipolar fuzzy sets in U will be denoted as .
In the following, we give an example for bipolar fuzzy set.
Example 1.
Let . is a bipolar fuzzy set on U.
Definition 2
([]). The empty bipolar fuzzy set is defined as , for each and denoted by .
The whole bipolar fuzzy set is defined as and , for each and denoted by .
With the following definition, we give the definitions of some set operations.
Definition 3
([]). Let . Then;
(1) and , for all .
(2) and , for all .
(3) , where and
(4) , where and
(5) .
Proposition 1
([]). Let and . Then we have the following:
(1)
(2)
(3)
(4) and .
(5) and .
(6)
Definition 4
([]). Let be a function and , . The image of a bipolar fuzzy set A is a bipolar fuzzy set on V, and it is defined by
where
,
The preimage of a bipolar fuzzy set B is a bipolar fuzzy set on U and it is defined by
.
Theorem 1
([]). Let be a function and , and ,. Then we have the following:
If , then .
If , then .
. If g is injective, then the equality holds.
. If g is surjective, then the equality holds.
, .
, .
Definition 5
([]). Let , and .
(1) is called bipolar fuzzy point in U, if for every
is called the value of this point and u is called the support of the bipolar fuzzy point .
For simplicity, we will denote bipolar fuzzy point by instead of .
(2) If and , then is called belong to A and denoted by .
The set of all bipolar fuzzy points in U will be denoted by .
, for each .
Theorem 2
([]). Let and . If , then .
Proof.
Let and . Then and . We have and . Hence and . Therefore, . □
Theorem 3
([]). Let and . Then
(i) and ,
(ii) If or , then
Proof.
(ii) Let or . Then , or , . Thus, or and or . Hence and and so . □
Theorem 4
([]). Let and . Then,
(i) .
(ii) If there exists a such that , then
Proof.
(ii) It is easy to see from and Theorem 2. □
Definition 6
([]). Let U be a nonempty set and . Then τ is called a bipolar fuzzy topology on U if it satisfies the following conditions;
(1) ,
(2) , for any ,
(3) , for .
The pair is said to be bipolar fuzzy topological space. Members of τ are called bipolar fuzzy open sets, and members whose complements belong to τ are called bipolar fuzzy closed sets.
Definition 7
([]). Let . Then τ is called a bipolar fuzzy supra topology on U if it satisfies the following conditions;
(1) ,
(2) , for .
The pair is said to be bipolar fuzzy supra topological space. Members of τ are called bipolar fuzzy supra open sets, and members whose complements belong to τ are called bipolar fuzzy supra closed sets.
The family of all bipolar fuzzy supra topologies on U will be denoted by .
Example 2
([]).
- Let U be a nonempty set and . In this case, is a bipolar fuzzy supra topology on U. is called discrete bipolar fuzzy supra topology and is called discrete bipolar fuzzy supra topological space.
- Let U be a nonempty set and . In this case, is a bipolar fuzzy supra topology on U. is called indiscrete bipolar fuzzy supra topology and is called indiscrete bipolar fuzzy supra topological space.
- Let be a bipolar fuzzy supra topological space. The families and are two fuzzy supra topologies in the sense of Abd-El Monsef and Ramadan [].
Theorem 5
([]). Let . Then the family of defined as is a bipolar fuzzy topology on X and .
Theorem 6
([]). Let κ be the family of all bipolar fuzzy supra closed sets in the bipolar fuzzy supra topological space . Then we have following:
(1) ,
(2) , for .
Theorem 7
([]). Let be a bipolar fuzzy topological space and τ be a bipolar fuzzy supra topology on U. We call τ a bipolar fuzzy supra topology associated with if .
Theorem 8
([]). Let and be two bipolar fuzzy supra topological spaces and be a mapping. f is called bipolar fuzzy supra continuous, if , for each .
3. Neighborhood Structure of Bipolar Fuzzy Supra Topological Spaces
In this section, we introduce the concept of neighborhood structure of a bipolar fuzzy point and generate a bipolar fuzzy supra topology by using the system of neighborhood.
Definition 8.
Let be a bipolar fuzzy supra topological space, and . A is called a bipolar fuzzy supra neighborhood of if there exists a bipolar fuzzy supra open set B in U such that .
The family of all bipolar fuzzy supra neighborhoods of is called the bipolar fuzzy supra neighborhood system of and denoted by .
Example 3.
Let and where
, ,
.
Let take two bipolar fuzzy points on U such that and
. Hence, we have the inclusions such that and
, so and .
Example 4.
Let and . For each , and and membership functions given by
, and ,
One can easily see that with the help of the graphs of membership functions given in Figure 2 and Figure 3.
Figure 2.
Positive membership degrees of open sets.
Figure 3.
Negative membership degrees of open sets.
It is clear that is a bipolar fuzzy supra topology on U. Therefore, for , we have
, and , and . So, we obtain .
With the following theorem, we characterize open sets by using neighborhoods.
Theorem 9.
Let be a bipolar fuzzy supra topological space and . Then A is a bipolar fuzzy supra open set if and only if A is a bipolar fuzzy supra neighborhood of each of its bipolar fuzzy points.
Proof.
Let A be a bipolar fuzzy supra open set and , then by taking , we obtain A is a bipolar fuzzy supra neighborhood of .
Conversely, suppose that A is a bipolar fuzzy supra neighborhood of each of its bipolar fuzzy points. Then, for every , there exists a bipolar fuzzy supra open set such that . Let . From the definition of bipolar fuzzy supra topology, C is a bipolar fuzzy supra open set. holds because for every . Otherwise, every bipolar fuzzy point of A belongs to , and therefore, they belong to C. Finally, we conclude that and . This means that A is bipolar fuzzy supra open set. □
Now, we give the basic properties of the bipolar fuzzy supra neighborhood.
Theorem 10.
Let be a bipolar fuzzy supra topological space and be the neighborhood system of bipolar fuzzy point . Then we have the following:
N1. for every .
N2. If , then .
N3. If and , then .
N4. Let . Then there exists such that and , .
Proof.
N1. Let . Since is a bipolar fuzzy supra open set, then is a neighborhood of each of its bipolar fuzzy points. Therefore .
N2. Let , then there exists bipolar fuzzy supra open set C such that , so .
N3. Let and . Then there exists a bipolar fuzzy supra open set C such that . Since , then and .
N4. Let . Then there exists such that . Let put a period. Thus we have . Now, let take , then . Since , it follows that . □
After proving the last two theorems, we should have a bipolar fuzzy supra topology determined by the neighborhood systems of a bipolar fuzzy point in a bipolar fuzzy supra topological space.
Theorem 11.
Let be a nonempty collection of bipolar fuzzy sets on U satisfying (N1)–(N4), for each bipolar fuzzy point . Then the family is a bipolar fuzzy supra topology on U such that is the family of all neighborhoods of in .
Proof.
Let the subfamily satisfy (N1)–(N4) for each and let . First, we need to see that is a bipolar fuzzy supra topology on U.
Since contains no bipolar fuzzy points then . We have . There must be a bipolar fuzzy supra neighborhood of each bipolar fuzzy points in U, which is , so .
Let and . If for any , then . Since and , we have . Therefore, is bipolar fuzzy supra topology on U.
For the remaining part of the proof, we need to show that is determined by a unique bipolar fuzzy supra neighborhood system, that is . For each there exists a such that . Since and , we have and . Hence, .
Conversely, let . Then, there exists a such that and for every . It yields that . This implies that the bipolar fuzzy supra open set B is a bipolar fuzzy supra neighborhood of so . Since we have . Then we conclude that . Hence we obtain . This completes the proof. □
Here, we present the characterization of continuous mapping by using bipolar fuzzy supra neighborhood.
Theorem 12.
Let and be two bipolar fuzzy supra topological space, and be a mapping. Then the following are equivalent:
1. f is a bipolar fuzzy supra continuous mapping.
2. for each .
3. For each and there exists such that .
Proof.
() Suppose that is a bipolar fuzzy supra continuous mapping. If we take then it is obvious that there exists a such that . Since f is bipolar fuzzy supra continuous we have and therefore and is valid. Hence this implies that .
() Let . By hypothesis we obtain . Let choose one can easily see that .
() To prove this statement we will show that for each . By taking , we obtain and thus for each . From the hypothesis there exists such that . Then, by the properties of image and preimage, we have . Finally for each . Hence . □
4. Q-Neighborhood Structure of Bipolar Fuzzy Supra Topological Spaces
In 1980, Ming et al. [] defined the concepts of quasi-coincident and Q-neighborhood. In this section, these two concepts are going to extend to bipolar fuzzy sets, and this allows us to study the Q-neighborhood structure of bipolar fuzzy supra topological spaces.
Definition 9.
1. Let . Then we say that A is called quasi-coincident with B iff and for . It is denoted by .
2. Bipolar fuzzy point is called quasi-coincident with A iff and . It is denoted by and opposite situation is denoted as .
In the following, we give an example of a quasi-coincident structure:
Example 5.
Let and . We obtain and for each and thus .
Now, we offer some fundamental properties related to the concept of quasi-coincident.
Theorem 13.
Let and . Then, we have the statements below:
1. .
2. .
3. .
4. .
5. .
6. .
7. .
8. .
9. such that .
10. .
11. Let . If , then .
Proof.
1, 2, and 3 are clear from the definition.
4.
| ⇔ | ||
| ⇔ | ||
| ⇔ | . |
5.
| ⇔ | ||
| ⇔ | ||
| ⇔ | . |
6. Suppose that . Then and for each . We can write the following inequality
| = | ||
| ≤ | ||
| = | 1 |
and therefore .
For the negative part, we have
| = | ||
| ≥ | ||
| = |
By combining the two inequalities, we obtain . Converse of the theorem can be shown by the same token.
7.
| ⇒ | ||
| ⇒ | ||
| ⇒ | ||
| ⇒ | . |
8. and . Thus, we obtain .
9. Let and . Hence, we obtain and . By taking and we have what we desired. Thus, .
Conversely, suppose that and . Then, and . From here, and and these inequalities give the result which is .
10.
| ⇔ | ||
| ⇔ | ||
| ⇔ | ||
| ⇔ | . |
11. Let and be given. Then it follows that and . Since , we write and . Finally, we conclude that . □
Proposition 2.
Let and . Then the following are hold:
1. .
2. .
Proof.
1. Let . Then we have and . Since and , we obtain and . Hence, .
Conversely, let . Then, and .
⇒ and .
⇒
2.
| ⇔ | □ | ||
| ⇔ | |||
| ⇔ | |||
| ⇔ | . |
Definition 10.
Let τ be a bipolar fuzzy supra topology on U, and . A is called Q-neighborhood of if there exists such that and . The family of all Q-neighborhood of the is denoted by .
Example 6.
Let and , where . Take . Since and it follows that .
In the next example, we see that a Q-neighborhood of bipolar fuzzy point generally may not contain the point itself.
Example 7.
Let take a bipolar fuzzy supra topology as , where , . Now if we take , we thus have and , therefore . Considering the given data we obtain and , so .
In the following theorem, we study the basic properties of the bipolar fuzzy supra Q-neighborhood.
Theorem 14.
Let be a bipolar fuzzy supra topological space and be the family of all Q neighborhoods of . Then we have the following:
Q1. and if , then .
Q2. If and , then .
Q3. Let . Then there exists such that and , .
Proof.
Q1. To see we need to show that there exists satisfying and for any . If we choose , then we are done. Now, let . Then there exists such that and holds. From here, and , consequently .
Q2. Let and . Then there exists such that and . Since , and .
Q3. Let . Then there exists such that and . By choosing we obtain . Moreover, since , then B is a Q neighborhood of any bipolar fuzzy points that are contained in it. So and . □
Theorem 15.
Let be nonempty collection of bipolar fuzzy sets on U satisfying (Q1)–(Q3) for each bipolar fuzzy point . Then the family is a bipolar fuzzy supra topology on U such that is the family of all Q-neighborhoods of in .
Proof.
Let the subfamily satisfies the conditions (Q1)–(Q3) for each and let . Firstly, we need to show that is a bipolar fuzzy supra topology. From the definition of , we have and by Theorem 14. Now let , then , we have and . Hence, . Furthermore, for every and , we have and , then it follows that . Finally we conclude that .
Now we show that . Suppose that . Then we have such that and . Then and thus . So, we obtain . For the converse , take . By the Theorem 14 there exists such that for every we have and . Moreover, , then and . Since , . Hence, we have . □
5. Bipolar Fuzzy Supra Topology in Data Mining
In the last section, we give an application of bipolar fuzzy set in methodical approach for medical diagnosis problems. The methodical technique to select the appropriate qualities and alternatives in the decision-making problem is given in the following stages. Here, we employ the method in [].
Step 1: Problem Area Selection:
Examine multi-criteria decision-making problems involving m attributes and n alternatives and p attributes , ().

All attributes and are bipolar fuzzy numbers for , , .
Step 2: Form bipolar fuzzy supra topologies for () and ():
(i) , where and .
(ii) , where and .
Step 3: Find Bipolar fuzzy score functions:
Bipolar fuzzy score functions (BFSF) of and are defined as follows:
(i) and , where t is the number of elements of F.
, for .
(ii) and , where s is the number of elements of H.
, for .
Step 4: Final Decision:
Determine bipolar fuzzy score values for the alternatives and the attributes . Select the attribute for the alternative , for alternative and for alternative , etc. If , then ignore , where .
Case Study
Dealing with uncertainty is inherent in medical diagnosis problems, and the introduction of bipolar fuzzy sets offers a valuable perspective. In this section, we present an illustrative medical diagnosis problem to demonstrate the applicability of the mentioned approach.
Step 1: Problem Area Selection:
Suppose that be the set of patients,
be the set symptoms and
be the set of diseases corresponding to the symptoms S.
We need to find the patient and to find the disease of the patient.
| Patient−Symptom Relation | ||||
| Symptoms | Patients | |||
| P1 | P2 | P3 | P4 | |
| Temperature | (0.8, −0.1) | (0.4, −0.5) | (0.5, −0.6) | (0.9, −0.4) |
| Cough | (0.3, −0.5) | (0.4, −0.8) | (0.6, −0.4) | (0.9, −0.2) |
| Blood Plates | (0.1, −0.3) | (0.7, −0.2) | (0.3, −0.9) | (0.4, −0.7) |
| Joint pain | (0.4, −0.5) | (0.6, −0.5) | (0.6, −0.3) | (0.5, −0.7) |
| Insulin | (0.8, −0.2) | (0.7, −0.3) | (0.3, −0.6) | (0.2, −0.5) |
| Symptom-Disease Relation | |||||
| Diagnosis | Symptoms | ||||
| Temperature | Cough | Blood Plates | Joint pain | Insulin | |
| Tuberculosis | (0.6, −0.1) | (0.9, −0.1) | (0, −0.8) | (0, −0.8) | (0, −0.9) |
| Diabetes | (0.1, −0.8) | (0.1, −0.8) | (0.2, −0.1) | (0.2, −0.5) | (0.9, −0.1) |
| Chikungunya | (0.9, −0.1) | (0, −0.8) | (0.7, −0.1) | (0.9, −0.1) | (0.2, −0.8) |
| Swine Flue | (0.2, −0.3) | (0.1, −0.3) | (0.2, −0.1) | (0.1, −0.5) | (0.2, −0.1) |
| Dengeu | (0.9, −0.1) | (0.2, −0.4) | (0.2, −0.4) | (0.3, −0.7) | (0.2, −0.7) |
Step 2: Form bipolar fuzzy supra topologies for () and ():
For ();
(i) , where
and .
We omit some bipolar fuzzy sets of F which are in E and we obtain .
(ii) , where
and = .
(iii) , where
and = .
(iv) , where
and = .
For ();
(i) , where
and .
We omit some bipolar fuzzy sets of H which are in G and we obtain
.
(ii) , where
and = .
(iii) , where
and = .
(iv) , where
and = .
(v) , where
and = .
Step 3: Find Bipolar fuzzy score functions:
For ,
(i) and , where . .
(ii) and , where . .
(iii) and , where . .
(iv) and , where . .
For ,
(i) and , where . .
(ii) and , where . .
(iii) and , where . .
(iv) and , where . .
(v) and , where . .
Step 4: Final Decision:
By organizing bipolar fuzzy score values for the alternatives and the attributes in ascending order, we obtain the following order and . Thus the patient suffers from dengue, the patient suffers from chikungunya, the patient suffers from diabetes, the patient suffers form tuberculosis.
6. Conclusions
With this study, we focus on the notions of bipolar fuzzy neighborhoods and the Q-neighborhood of a bipolar fuzzy point in bipolar fuzzy supra topological spaces and also investigate the necessary conditions for a family of bipolar fuzzy sets to generate a bipolar fuzzy supra topology. Finally, we present a method for data analysis under a bipolar fuzzy supra topological environment as a real-life application. These concepts play useful roles in further research. Generalizations of fuzzy sets have been successfully used in various fields such as economics, environmental science, engineering, and especially in decision-making problems. A bipolar fuzzy set is a new kind of fuzzy set dealing with positive and negative aspects. In recent years, some of the other fuzzy set generalizations have been combined with a bipolar fuzzy set; for instance, bipolar intuitionistic fuzzy sets [], bipolar picture fuzzy set []. With the help of these novel fuzzy sets, similar applications may be studied by defining the supra topology, and also this theory can be developed in other research areas of general topology.
Author Contributions
Conceptualization, B.P.V.; Software, B.P.V.; Formal analysis, H.M.; Investigation, H.M.; Resources, B.P.V.; Data curation, ¸H.M.; Writing—original draft, B.P.V.; Supervision, B.P.V.; Project administration, B.P.V. All authors contributed equally in writing this article. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Data Availability Statement
Data are contained within the article.
Conflicts of Interest
The authors declare no conflict of interest.
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