Next Article in Journal
Computational Prediction of the Epitopes of HA1 Protein of Influenza Viruses to its Neutralizing Antibodies
Next Article in Special Issue
Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy
Previous Article in Journal / Special Issue
A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site
Article Menu

Export Article

Open AccessReview
Antibodies 2019, 8(1), 1; https://doi.org/10.3390/antib8010001

Single-Domain Antibodies and Their Formatting to Combat Viral Infections

1
VIB Center for Medical Biotechnology, 9052 Ghent, Belgium
2
Department of Biochemistry and Microbiology, Ghent University, 9052 Ghent, Belgium
3
Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Received: 30 November 2018 / Revised: 13 December 2018 / Accepted: 14 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Nanobody)
Full-Text   |   PDF [5806 KB, uploaded 20 December 2018]   |  
  |   Review Reports

Abstract

Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as Nanobodies®, have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of production and formatting flexibility favor VHHs over conventional antibody formats for many applications. The exceptional ease by which it is possible to fuse VHHs with different molecular modules has been particularly explored in the context of viral infections. In this review, we focus on VHH formats that have been developed to combat viruses including influenza viruses, human immunodeficiency virus-1 (HIV-1), and human respiratory syncytial virus (RSV). Such formats may significantly increase the affinity, half-life, breadth of protection of an antiviral VHH and reduce the risk of viral escape. In addition, VHHs can be equipped with effector functions, for example to guide components of the immune system with high precision to sites of viral infection. View Full-Text
Keywords: virus; nanobody; formatting; Fc-domain; half-life virus; nanobody; formatting; Fc-domain; half-life
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

De Vlieger, D.; Ballegeer, M.; Rossey, I.; Schepens, B.; Saelens, X. Single-Domain Antibodies and Their Formatting to Combat Viral Infections. Antibodies 2019, 8, 1.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top