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Article

Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein

1
HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA
2
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
3
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
4
Department of Immunology, UT Southwestern Medical Center Dallas, TX 75390, USA
5
Otsuka Pharmaceutical Co., Ltd., Osaka 540-0021, Japan
*
Author to whom correspondence should be addressed.
Antibodies 2017, 6(3), 11; https://doi.org/10.3390/antib6030011
Received: 10 May 2017 / Revised: 14 June 2017 / Accepted: 1 August 2017 / Published: 23 August 2017
(This article belongs to the Special Issue Monoclonal Antibodies)
Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3—specific for the central repeat region—have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s. View Full-Text
Keywords: Plasmodium falciparum; circumsporozoite protein; CSP; monoclonal antibody; 2A10; 3C1; 3C2; 3D3 Plasmodium falciparum; circumsporozoite protein; CSP; monoclonal antibody; 2A10; 3C1; 3C2; 3D3
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MDPI and ACS Style

Zhang, M.; Mandraju, R.; Rai, U.; Shiratsuchi, T.; Tsuji, M. Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies 2017, 6, 11. https://doi.org/10.3390/antib6030011

AMA Style

Zhang M, Mandraju R, Rai U, Shiratsuchi T, Tsuji M. Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein. Antibodies. 2017; 6(3):11. https://doi.org/10.3390/antib6030011

Chicago/Turabian Style

Zhang, Min, Rajakumar Mandraju, Urvashi Rai, Takayuki Shiratsuchi, and Moriya Tsuji. 2017. "Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein" Antibodies 6, no. 3: 11. https://doi.org/10.3390/antib6030011

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