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Addendum published on 22 September 2015, see Antibodies 2015, 4(3), 278.
Open AccessArticle

Polyclonal Antibody Therapies for Clostridium difficile Infection

1
Secretory IgA, Inc., Ann Arbor, and Allergy and Clinical Immunology, William Beaumont Hospital, Royal Oak, MI 48073, USA
2
Secretory IgA, Inc., Ann Arbor, MI, USA
3
Secretory IgA, Inc., Ann Arbor, MI, USA
*
Author to whom correspondence should be addressed.
Antibodies 2014, 3(4), 272-288; https://doi.org/10.3390/antib3040272
Received: 26 August 2014 / Revised: 18 September 2014 / Accepted: 28 September 2014 / Published: 28 October 2014
(This article belongs to the Special Issue Antibodies Therapies against Infectious Diseases)
Clostridium difficile infection has emerged as a growing worldwide health problem. The colitis of Clostridium difficile infection results from the synergistic action of C. difficile secreted toxins A and B upon the colon mucosa. A human monoclonal IgG anti-toxin has demonstrated the ability in combination therapy to reduce mortality in C. difficile challenged hamsters. This antibody is currently in a clinical trial for the treatment of human Clostridium difficile infection. More than one group of investigators has considered using polyclonal bovine colostral antibodies to toxins A and B as an oral passive immunization. A significant proportion of the healthy human population possesses polyclonal antibodies to the Clostridium difficile toxins. We have demonstrated that polyclonal IgA derived from the pooled plasma of healthy donors possesses specificity to toxins A and B and can neutralize these toxins in a cell-based assay. This suggests that secretory IgA prepared from such pooled plasma IgA may be able to be used as an oral treatment for Clostridium difficile infection. View Full-Text
Keywords: Clostridium difficile; toxins A and B; polyclonal IgG; monoclonal IgG; polyclonal IgA; secretory IgA Clostridium difficile; toxins A and B; polyclonal IgG; monoclonal IgG; polyclonal IgA; secretory IgA
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Simon, M.R.; Chervin, S.M.; Brown, S.C. Polyclonal Antibody Therapies for Clostridium difficile Infection. Antibodies 2014, 3, 272-288.

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