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Urban Groundwater Contamination by Non-Steroidal Anti-Inflammatory Drugs

Institute of Environmental Assessment & Water Research (IDAEA), CSIC, c/Jordi Girona 18-26, 08034 Barcelona, Spain
Author to whom correspondence should be addressed.
Academic Editor: Aldo Fiori
Water 2021, 13(5), 720;
Received: 4 February 2021 / Revised: 1 March 2021 / Accepted: 3 March 2021 / Published: 6 March 2021
(This article belongs to the Special Issue Urban Groundwater)
Pharmaceuticals, such as non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites, have become a major concern due to their increasing consumption and their widespread occurrence in the environment. In this paper, we investigate the occurrence of NSAIDs and their metabolites in an urban aquifer, which may serve as a potential resource for drinking water, and propose a methodology to assess the removal of these substances in the river–groundwater interface. Then, risk quotients (RQs) are computed, in order to determine the risk posed by the single NSAIDs and their mixture to human health. To this end, six NSAIDs and two metabolites were collected from an urban aquifer located in the metropolitan area of Barcelona (NE, Spain), in which the major pollution source is a contaminated river. All of the target NSAIDs were detected in groundwater samples, where the concentrations in the aquifer were higher than those found in the river water (except for ibuprofen). Diclofenac, ketoprofen, propyphenazone and salicylic acid were detected at high mean concentrations (ranging from 91.8 ng/L to 225.2 ng/L) in the aquifer. In contrast, phenazone and mefenamic acid were found at low mean concentrations (i.e., lower than 25 ng/L) in the aquifer. According to the proposed approach, the mixing of river water recharge into the aquifer seemed to some extent to promote the removal of the NSAIDs under the sub-oxic to denitrifying conditions found in the groundwater. The NSAIDs that presented higher mean removal values were 4OH diclofenac (0.8), ibuprofen (0.78), salicylic acid (0.35) and diclofenac (0.28), which are likely to be naturally attenuated under the aforementioned redox conditions. Concerning human health risk assessment, the NSAIDs detected in groundwater and their mixture do not pose any risk for all age intervals considered, as the associated RQs were all less than 0.05. Nevertheless, this value must be taken with caution, as many pharmaceuticals might occur simultaneously in the groundwater. View Full-Text
Keywords: water management; urban aquifer; redox conditions; pharmaceuticals; metabolites; human health risk assessment water management; urban aquifer; redox conditions; pharmaceuticals; metabolites; human health risk assessment
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MDPI and ACS Style

Jurado, A.; Vázquez-Suñé, E.; Pujades, E. Urban Groundwater Contamination by Non-Steroidal Anti-Inflammatory Drugs. Water 2021, 13, 720.

AMA Style

Jurado A, Vázquez-Suñé E, Pujades E. Urban Groundwater Contamination by Non-Steroidal Anti-Inflammatory Drugs. Water. 2021; 13(5):720.

Chicago/Turabian Style

Jurado, Anna, Enric Vázquez-Suñé, and Estanislao Pujades. 2021. "Urban Groundwater Contamination by Non-Steroidal Anti-Inflammatory Drugs" Water 13, no. 5: 720.

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