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Article

Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays

1
Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226-1, 1040 Vienna, Austria
2
Faculty of Environment and Natural Resources, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 70000, Vietnam
3
Viet Nam National University Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City 70000, Vietnam
4
BioDetection Systems bv, Science Park 406, 1098 XH Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editors: Martin Wagner and Sonja Bauer
Water 2021, 13(22), 3245; https://doi.org/10.3390/w13223245
Received: 29 September 2021 / Revised: 8 November 2021 / Accepted: 13 November 2021 / Published: 16 November 2021
A set of CALUX in vitro bioassays was applied for long-term toxicity monitoring at an advanced wastewater treatment plant comprising ozonation and granular activated carbon filtration for the abatement of contaminants of emerging concern (CEC). During the 13-month monitoring, eight reporter gene assays targeting different modes of action along the cellular toxicity pathway were accessed to evaluate the suitability and robustness of the technologies. Two approaches were followed: on the one hand, signal reduction during advanced treatment was monitored; on the other hand, results were compared to currently available effect-based trigger values (EBTs). A decrease of the corresponding biological equivalent concentrations after the multibarrier system could be observed for all modes of action; while the estrogenic activity decreased below the EBT already during ozonation, the potencies of oxidative stress-like and toxic PAH-like compounds still exceeded the discussed EBT after advanced treatment. Overall, the long-term monitoring confirmed the positive effect of the multibarrier system, commonly evaluated only by CEC abatement based on chemical analysis. It could be demonstrated that advanced WWTPs designed for CEC abatement are suitable to significantly decrease toxicity responses not only in the frame of pilot studies but under real-world conditions as well. View Full-Text
Keywords: ozonation; granular activated carbon; CALUX reporter gene bioassays; effect-based trigger value; urban wastewater ozonation; granular activated carbon; CALUX reporter gene bioassays; effect-based trigger value; urban wastewater
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MDPI and ACS Style

Phan, L.T.; Schaar, H.; Reif, D.; Weilguni, S.; Saracevic, E.; Krampe, J.; Behnisch, P.A.; Kreuzinger, N. Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays. Water 2021, 13, 3245. https://doi.org/10.3390/w13223245

AMA Style

Phan LT, Schaar H, Reif D, Weilguni S, Saracevic E, Krampe J, Behnisch PA, Kreuzinger N. Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays. Water. 2021; 13(22):3245. https://doi.org/10.3390/w13223245

Chicago/Turabian Style

Phan, Lam T., Heidemarie Schaar, Daniela Reif, Sascha Weilguni, Ernis Saracevic, Jörg Krampe, Peter A. Behnisch, and Norbert Kreuzinger. 2021. "Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays" Water 13, no. 22: 3245. https://doi.org/10.3390/w13223245

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