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Genes 2018, 9(9), 452; https://doi.org/10.3390/genes9090452

Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews

1
Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
2
Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China
3
Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
Received: 23 July 2018 / Revised: 21 August 2018 / Accepted: 21 August 2018 / Published: 7 September 2018
(This article belongs to the Special Issue Evolutionary Medicine)
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Abstract

The derived human alcohol dehydrogenase (ADH)1B*48His allele of the ADH1B Arg48His polymorphism (rs1229984) has been identified as one component of an East Asian specific core haplotype that underwent recent positive selection. Our study has been extended to Southwest Asia and additional markers in East Asia. Fst values (Sewall Wright’s fixation index) and long-range haplotype analyses identify a strong signature of selection not only in East Asian but also in Southwest Asian populations. However, except for the ADH2B*48His allele, different core haplotypes occur in Southwest Asia compared to East Asia and the extended haplotypes also differ. Thus, the ADH1B*48His allele, as part of a core haplotype of 10 kb, has undergone recent rapid increases in frequency independently in the two regions after divergence of the respective populations. Emergence of agriculture may be the common factor underlying the evident selection. View Full-Text
Keywords: alcohol dehydrogenase; population genetics; genetic selection alcohol dehydrogenase; population genetics; genetic selection
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Gu, S.; Li, H.; Pakstis, A.J.; Speed, W.C.; Gurwitz, D.; Kidd, J.R.; Kidd, K.K. Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews. Genes 2018, 9, 452.

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