Next Article in Journal
Nitrogen Supply and Leaf Age Affect the Expression of TaGS1 or TaGS2 Driven by a Constitutive Promoter in Transgenic Tobacco
Next Article in Special Issue
L Chromosome Behaviour and Chromosomal Imprinting in Sciara Coprophila
Previous Article in Journal
Habitat Fragmentation Reduces Genetic Diversity and Connectivity of the Mexican Spotted Owl: A Simulation Study Using Empirical Resistance Models
Previous Article in Special Issue
Transmission and Drive Involving Parasitic B Chromosomes
Open AccessArticle

Sequencing of Supernumerary Chromosomes of Red Fox and Raccoon Dog Confirms a Non-Random Gene Acquisition by B Chromosomes

Institute of Molecular and Cellular Biology Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
Novosibirsk State University, 630090 Novosibirsk, Russia
Theodosius Dobzhansky Center for Genome Bioinformatics, Saint-Petersburg State University, 199004 Saint-Petersburg, Russia
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Cambridge Resource Centre for Comparative Genomics, Department of Veterinary Medicine, Cambridge University, Cambridge CB3 0ES, UK
Author to whom correspondence should be addressed.
Genes 2018, 9(8), 405;
Received: 6 July 2018 / Revised: 29 July 2018 / Accepted: 7 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Evolution, Composition and Regulation of Supernumerary B Chromosomes)
B chromosomes (Bs) represent a variable addition to the main karyotype in some lineages of animals and plants. Bs accumulate through non-Mendelian inheritance and become widespread in populations. Despite the presence of multiple genes, most Bs lack specific phenotypic effects, although their influence on host genome epigenetic status and gene expression are recorded. Previously, using sequencing of isolated Bs of ruminants and rodents, we demonstrated that Bs originate as segmental duplications of specific genomic regions, and subsequently experience pseudogenization and repeat accumulation. Here, we used a similar approach to characterize Bs of the red fox (Vulpes vulpes L.) and the Chinese raccoon dog (Nyctereutes procyonoides procyonoides Gray). We confirm the previous findings of the KIT gene on Bs of both species, but demostrate an independent origin of Bs in these species, with two reused regions. Comparison of gene ensembles in Bs of canids, ruminants, and rodents once again indicates enrichment with cell-cycle genes, development-related genes, and genes functioning in the neuron synapse. The presence of B-chromosomal copies of genes involved in cell-cycle regulation and tissue differentiation may indicate importance of these genes for B chromosome establishment. View Full-Text
Keywords: supernumerary chromosomes; karyotype evolution; genome instability supernumerary chromosomes; karyotype evolution; genome instability
Show Figures

Figure 1

MDPI and ACS Style

Makunin, A.I.; Romanenko, S.A.; Beklemisheva, V.R.; Perelman, P.L.; Druzhkova, A.S.; Petrova, K.O.; Prokopov, D.Y.; Chernyaeva, E.N.; Johnson, J.L.; Kukekova, A.V.; Yang, F.; Ferguson-Smith, M.A.; Graphodatsky, A.S.; Trifonov, V.A. Sequencing of Supernumerary Chromosomes of Red Fox and Raccoon Dog Confirms a Non-Random Gene Acquisition by B Chromosomes. Genes 2018, 9, 405.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop